Journal of Oriental Neuropsychiatry (동의신경정신과학회지)

The Korean Society of Oriental Neuropsychiatry (대한한방신경정신과학회)
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The effects of Sahyangsohapwon on Learning and Memory of AD Rats using Morris water maze and Radial arm maze paradigm

사향소합원(麝香蘇合元)이 Alzheimer's disease 모델 백서의 학습과 기억에 미치는 영향

  • Whang Wei-Wan (Dept. of Oriental Neuropsychiatry, College of Oriental Medicine, Kyung Hee University)
  • 황의완 (경희대학교 한의과대학 신경정신과 교실)
  • Published : 1999.08.30
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Abstract

The effects of Sahyangsohapwon on the enhancement of learning and memory of AD model rats were studied with Morris water maze and radial arm maze. Sample group was electrolytically lesioned on nbM, and then daily treated with the medicine for two months. Control group with nbM lesion, and sham group with the sham operation were treated the vehicle for same duration. The following results were observed. In the learning trials of Morris water maze, all three groups were improved in learning capacity as trials were repeated, but the sham group showed more prominent improvement in learning compared with the control group(p<0.01). 2. In memory retention test of Morris water maze, the sham group marked more significant improvement statistically in memory retention compared with the control group(p<0.05). 3. In the learning of radial arm maze, the sham group shows better learning capacity significantly compared with the control group(p<0.05). With the experimental results above, Sahyangsohapwon can be supposed to have the improving effects on the learning and memory of AD rats induced by electronical injury of nbM.

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