Effects of Uncaria Rhynchophylla on Vestibular Compensation in Unilateral Labyrinthectomized Rats

조구등(釣鉤藤)이 일측(一側) 전정기관(前庭器官) 손상(損像) 흰쥐의 전정보상(前庭補償)에 미치는 영향(影響)

  • Song, Jin-Ho (Department of Physiology, School of Medicine & MRRC, Wonkwang University) ;
  • Lee, Sung-Ho (Department of Physical Education, College of Education, Wonkwang University) ;
  • Kim, Min-Sun (Department of Physiology, School of Medicine & MRRC, Wonkwang University) ;
  • Sohn, In-Chul (Department of Acupuncture & Moxibustion, College of Oriental Medicine, Wonkwang University) ;
  • Park, Byung-Rim (Department of Physiology, School of Medicine & MRRC, Wonkwang University) ;
  • Kim, Jae-Hyo (Department of Acupuncture & Moxibustion, College of Oriental Medicine, Wonkwang University)
  • 송진호 (원광대학교 의과대학 생리학교실 & 의약자원연구센터) ;
  • 이성호 (원광대학교 사범대학교 체육교육과) ;
  • 김민선 (원광대학교 의과대학 생리학교실 & 의약자원연구센터) ;
  • 손인철 (원광대학교 한의과대학 경혈학교실) ;
  • 박병림 (원광대학교 의과대학 생리학교실 & 의약자원연구센터) ;
  • 김재효 (원광대학교 한의과대학 경혈학교실)
  • Published : 1999.09.30

Abstract

The purpose of this study was to asses the etlect of Uncaria rhynchophylla (UR). one of the oriental herbs having a capability to block calcium channels, on affecting vestibular compensation (VC) in Sprague - Dawley rats. Animals were divided into a drug treatment group receiving, UR per oral for 10 days preceding unilateral labyrinthectomy (ULX) and a control group with saline ingestion, To evaluate behavioral changes. horizontal spontaneous nystagmus (SN) and roll head tilt (RHT) were recorded by a video camem with zoom lens in the course of vestibular compensation (VC). Immunohistochemical staining was performed by conventional ABC method to visualize cFos-like immunoreactive (cFLI) neurons in the medial vestibular nuclei (MVN) and cFLI cells were counted by image analyzer. Bodyweight was increased significantly, about 35g, by UR treatment for 10 clays before ULX. Compared with the control group, the drug group showed significant reduction of RHT 6 hrs after ULX as well as fast disappearance of SN at early stages of vestibular compensation. Also, recovery of the spatial and temporal cFLI expressions in the bilateral MVN was accelerated 24 hrs after ULX. These results suggest that Uncaria rhynchophyila has a beneficial effect to ameliorate vestibular compensation in unilateral labryinthectomized rats.

Keywords

References

  1. Brain Res v.444 Neuronal activity in the ipsilateral medial vestibular nucleus of the guinea pig follwing unilateral labyrinthectomy Smith, P.F.;Curthoys, I.S.
  2. 中草藥 v.24 no.2 劉紅梅(等)
  3. 黃堤內經素問靈樞合編 張隱庵;馬元臺
  4. 韓藥臨床應用 陸昌洙(外)
  5. Exp Brain Res v.82 Compensation of horizontal canal related activity in the medial vestibular nucleus following unilateral labyrinth ablation in decerebrated gerbil Newlands, S.D.;Perachio, A.A.
  6. 實用中醫內科學 馬有度
  7. 常見病症辨證診治槪要 白洪龍
  8. 中醫內科辨證學 王顯明
  9. J. Virol v.42 Candidate product of the FBJ murine osteosarcoma virus ongogene: Characterization of a 55,00 dalton phosphoprotein Curran, T.;Teich, N.
  10. Annu Rev Neurosci v.14 Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun Morgan, J.I.;Curran, T.
  11. Neurosci Lett v.129 Electrical stimulation of visceral afferent pathways in the pelvic nerve increases c-fos in the rat lumbosacral spinal cord Birder, L.A.;Roppolo, J.R.;Iadarola, M.J.;De Groat, W.C.
  12. Nature v.340 Rapid increase of an immediate early gene messenger RNA in hippocampal neurons by synaptic NMDA receptor activation. Cole, A.J.;Saffen, D.W.;Baraban, J.M.;Worley, P.F.
  13. Neuroscience v.70 c-fos Expression in the rat brain after unilateral labyrinthectomy and its relation to the uncompensated and compensated stages Cirelli. C.;Pompeiano, M.;D'Ascanio, P.;Arrighi, P.;Pompeiano, O.
  14. Brain Res v.735 Temporal relationship between the expression of fos, jun and krox-24 in the guinea pig vestibular nuclei during the development of vestibular compensation for unilateral vestibular deafferentation Darlington, C.L.;Lawlor, P.;Smith, P.F.;Dragunow, M.
  15. Abst Society ForNeurosci v.752 Effects of electrical stimulation on VOR and c-Fos like protein expression of the medial vestibular nuclei following unilateral labyrinthectomy in rats Park, B.R.;Kim, M.S.;Lee, M.Y.;Kim, O.J.
  16. Otolaryngol Head Neck Surg v.107 Rehabilitation therapy for patients with disequilibrium and balance disorders. Konrad, H.R.;Tomlinson, D.;Stockwell, C.W.;Norre, M.;Horak, F.B.;Shepard, N.T.;Herdman, S.J.
  17. J Vestib Res v.4 Can vestibular compensation be enhanced by drug treatment? A review of recent evidence. Smith, P.F.;Darlington, C.L.
  18. 中草藥學(下冊) 南京藥學院
  19. Their occurrence and chemotaxonomy v.41 Alkaloids of Uncaria, part V Phillipson, J.D.;Hemingwa, S.R.;Ridsdale, C.E.
  20. Chinese drugs of plant origin ; Chemistry, pharmacology and use in traditional and modern medicine Tang, W.;Eisenbran, G.
  21. Chines Herbal Medicine-Materia Medica Bensky, D.;Gramble, A.
  22. Planta Med v.5 Hypotensive action of 3 alpha-dihydrocadambine, an indole alkaloid glycoside of Uncaria hooks Aisaka, K.;Hattori, Y.;Kihara, T.;Ishihara, T.;Endo, K.;Hikino, H.
  23. Nippon Yakurigaku Zasshi v.95 no.2 Vasodilative effects of indole alkaloids obtained from domestic plants, Uncaria rhynchophylla Miq. and Amsonia elliptica Roem. et Schult Ozaki, Y.
  24. Planta Med v.57 no.5 $Ca^{2+}$channel blocking effects of hirsutine, an indole alkaloid from Uncaria genus, in the isolated rat aorta Yano, S.;Horiuchi, H.;Horie, S.;Aimi, N.;Sakai, S.;Watanabe, K.
  25. 鍼灸學(上下) 全國韓醫科大學鍼灸經穴學敎室
  26. 申氏本草學 申佶求
  27. 原色臨床本草學 辛民敎
  28. Neurosci. Lett. v.222 Role of vestibulocerebellar N-methyl-D-aspartate receptors for behavioral recovery following unilateral labyrinthectomy in rats. Kim, M,S,;Jin, B.K.;Chun, S.W.;Lee, M.Y.;Lee, S.H.;Kim, J.H.;Park, B.R.
  29. Jpn J Pharmacol v.57 Inhibition of ion channels by hirsutine in rat pheochromocytoma cells Nakazawa, K.;Watano, T.;Ohara-Imaizumi, M.;Inoue, K.;Fujimori, K.;Ozaki, Y.;Harada, M.;Takanaka, A.
  30. J Laryngol Otol. v.97 no.8 Flunarizine in the treatment of vertigo Wouters, L.;Amery, W.;Towse, G.
  31. Aviat Space Environ Med. v.57 no.1 Calcium antagonists in the prevention of motion sickness Lee, J.A.;Watson, L.A.;Boothby, G.
  32. Ca2+ entry blocker flunarizine in vestibular compensation. In:Flohr H, ed. Post-lesion neural plasticity Tolu, E.;Mameli, O.;Caria, M.A.;Melis, F.
  33. Exp Brain Res. v.93 Injections of calmidazolium chloride into the ipsilateral medial vestibular nucleus or fourth ventricle reduce spontaneous ocular nystagmus following unilateral labyrinthectomy in guinea pigs Sansom, A.J.;Darlington, C.L.;Smith, P.F.;Gilchrist, D.P.D.;Keenan, C.J.;Kenyon, K.
  34. J Ethnopharmacol v.54 Application of radioligand receptor binding assays in the search for CNS active principles from Chinese medicinal plants. Zhu, M.;Bowery, N.G.;Greengrass, P.M.;Phillipson, J.D.
  35. Brain Res Rev v.20 Neurochemistry of the central vestibular pathways De Waele, C.;Muhlethaler, M.;Vidal, P.P.
  36. Brain Res Rev v.16 Neurochemical mechanisms of recovery from peripheral vestibular lesions (vestibular compensation) Smith, P.F.;Darlington, C.L.
  37. J Neurophysiol v.29 A mechanism of central compensation of vestibular function follwing hemilabyrinthectomy Precht, W.;Shimazu, H.;Markhan, C.H.
  38. Acta Otolaryngol v.76 The vestibular response following unilateral vestibular neurectomy Fisch, U.
  39. Brain Res Rev v.14 Mechanisms of recovery following unilateral labyrinthectomy : a review Smith, P.F.;Curthoy, I.S.