The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
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Inhibitory Effects of Allergic Reaction of Aqueous Extract of Salviae Radix Root by Anal Therapy

항장요법(肛腸療法)에 의한 단삼추출액(丹蔘抽出液)의 알레르기반응 억제효과(抑制效果)

  • Cho, Jung-Youn (Dept. of Internal Medicine, College of Oriental Medicine Wonkwang University) ;
  • Moon, Seok-Jae (Dept. of Internal Medicine, College of Oriental Medicine Wonkwang University) ;
  • Moon, Goo (Dept. of Internal Medicine, College of Oriental Medicine Wonkwang University) ;
  • Won, Jin-Hee (Dept. of Internal Medicine, College of Oriental Medicine Wonkwang University) ;
  • Kim, Hyung-Min (College of Pharmacy Wonkwang University)
  • 조정연 (원광대학교 한의과대학 비계내과학 교실) ;
  • 문석재 (원광대학교 한의과대학 비계내과학 교실) ;
  • 문구 (원광대학교 한의과대학 비계내과학 교실) ;
  • 원진희 (원광대학교 한의과대학 비계내과학 교실) ;
  • 김형민 (원광대학교 약학대학 한약학과)
  • Published : 1999.03.30
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Abstract

Dansam, the root of Salvia miltiorrhiza BGE. (Labiatae), has a bitter and a slightly 'cold' property. and is nontoxic. It has been used for the treatment of diseases such as tumors, bruises, gynecologic diseases, menoxenia, anemia and so forth. As an oriental medicine pathway, anal therapy has many kinds of treatments, Retention enema is one the most useful, advantageous methods of anal therapy. This experiment was performed in order to study the effect of an aqueous extract of Salviae radix root(SRRAE) on Immediate type allergic reaction by Retention enema. The results were obtained as follows, 1. SRRAE inhibited compound 48/80-induced Immediate type allergic reaction 100% with the dose of 0.1g/kg by anal treatment. However, SRRAE showed no significant inhibitory effect on the same reaction by oral treatment. When mice were pretreated with SRRAE at a concentration ranging from 0.001 to 1.0g/kg, by intra-anal treatment, the serum histamine levels were reduced in a dose-dependent manner. 2. SRRAE also inhibited by 79.8% local cutaneous allergic reaction activated by anti-dinitrophenyl (DNP) IgE. 3. SRRAE close-dependently inhibited the histamine release from rat peritoneal mast cells(RPMC) by anti-DNP IgE., but SRRAE not inhibited compound 48/80-induced histamine release. 4. SRRAE dose-dependently inhibited tumor necrosis $factor-\;{\alpha}$ $(TNF-\;{\alpha}$) production from RPMC by anti-DNP IgE. Moreover, the level of cAMP in RPMC, when SRRAE was added, significantly increased compared with that of a normal control. According to the above results, anal therapy(Retention enema) of SRRAE may be beneficial in the treatment of systemic and local Immediate type allergic reactions.

Keywords

References

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