Korean Journal of Food Science and Technology (한국식품과학회지)
- Volume 31 Issue 4
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- Pages.1057-1064
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- 1999
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- 0367-6293(pISSN)
Anti-hyperglycemic Effect of Cortex Mori radicis in db/db Mice
db/db 마우스에서 상백피의 혈당강하효과
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Kim, Youn-Young
(Department of Food and Nutrition, Kyunghee University) ;
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Choue, Ryo-Won
(Department of Food and Nutrition, Kyunghee University) ;
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Chung, Sung-Hyun
(Department of Pharmacy, Kyunghee University) ;
- Koo, Sung-Ja (Department of Food and Nutrition, Kyunghee University)
- Published : 1999.08.31
Abstract
Cortex Mori radicis has been used in the treatment of diabetes mellitus. In this study, the antihyperglycemic effect of Cortex Mori radicis was observed in obese diabetic mice(C57BLKsJ db/db). Cold water extract of Cortex Mori radicis was supplied in tab water(500, 1000 mg/kg/day) with normal chow for 5 weeks. Food intake and body weight gain were decreased significantly in experimental group. Also experimental group exhibited lower fasting serum glucose level when compaired to control group. Hb Alc level and triglyceride level were lowered in a dose-dependent manner. The activity of small intestinal disaccharidases was decreased at most segments. In conclusion, Cortex Mori radicis has anti-obesity effect to reduce food intake and body weight gain. And it is able to decrease the activity of small intestinal disaccharides and thus it can reduce serum glucose level and triglyceride level.
8주령의 C57BL/KsJ db/db마우스에 상백피 냉침추출물을 투여하면서 5주간 사육하여 식이섭취량, 체중변화, 혈중 포도당 농도를 관찰하고, 소장내