Korean Journal of Food Science and Technology (한국식품과학회지)
- Volume 31 Issue 3
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- Pages.831-837
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- 1999
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- 0367-6293(pISSN)
Modulation Effects of Antioxidant Vitamins on Ochratoxin A-induced Oxidative Toxicity in Mice
마우스에서 Ochratoxin A로 유발된 산화적 독성에 대한 항산화 비타민의 완화작용
- Park, Jung-Hyun (Department of Food Science and Technology, Gyeongsang National University) ;
- Kang, Sung-Jo (Institute of Agriculture and Fishery Development, Gyeongsang National University) ;
- Kang, Jin-Soon (Department of Home Economic, Chinju Technical College) ;
- Ryu, Jae-Chun (Toxicology Laboratory, Korea Institute of Science and Technology) ;
- Chung, Duck-Hwa (Department of Food Science and Technology, Gyeongsang National University)
- 박정현 (경상대학교 식품공학과) ;
- 강성조 (경상대학교 농어촌개발연구소) ;
- 강진순 (진주전문대학 가정과) ;
- 류재천 (한국과학기술연구원 독성연구팀) ;
- 정덕화 (경상대학교 식품공학과)
- Published : 1999.06.30
Abstract
Ochratoxin A (OA), a naturally occurring mycotoxin, has been known to cause renal and hepatic lesion in human and animals. This study was carried out to investigate the modulation effects of antioxidant vitamins on OA-induced lipid peroxidation associated with oxidative damage. Vitamin C (10 mg/kg/day) and vitamin E (63.8 mg/kg/day) were administered by intraperitoneal (i.p.) injection to male ICR mice, and 1 hr later, OA which was dissolved in 0.1 M
곰팡이 독소인 ochratoxin A (OA)는 동물과 사람에게 간 및 신장의 손상을 일으키는 것으로 알려져 있다. 본 연구는 산화적 손상과 관련이 있는 OA-유발 지질과산화에 대한 항산화 비타민의 완화작용에 대하여 조사하였다. 수컷 ICR 마우스에 비타민 C (10 mg/kg)와 비타민 E (63.8 mg/kg)를 복강 투여하고, 한 시간 후에 0.1M