Natural Product Sciences
- Volume 5 Issue 2
- /
- Pages.65-69
- /
- 1999
- /
- 1226-3907(pISSN)
- /
- 2288-9027(eISSN)
Cyclooxygenase-2 Inhibitor from Evodia rutaecarpa
-
Kang, Sam-Sik
(Natural Products Research Institute, Seoul National University)
;
-
Kim, Ju-Sun
(Natural Products Research Institute, Seoul National University)
;
-
Son, Kun-Ho
(Department of Food and Nutrition, Andong National University)
;
- Kim, Hyun-Pyo (College of Pharmacy, Kangwon National University) ;
- Chang, Hyeun-Wook (College of Pharmacy, Yeongnam University)
- Published : 1999.06.01
Abstract
By bioassay guided fractionation followed by chromatographic separation of the MeOH extract from the fruit of Evodia rutaecarpa (Juss.) Benth. (Rutaceae), a new cyclooxygenase-2 inhibitor was isolated and identified as an alkaloid, rutaecarpine. Other alkaloids such as evodiamine and dehydroevodiamine together with limonoids were also isolated and characterized.