The Korean Journal of Physiology and Pharmacology
- 제3권2호
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- Pages.165-174
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- 1999
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- 1226-4512(pISSN)
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- 2093-3827(eISSN)
Evidence for Adenosine Triphosphate (ATP) as an Excitatory Neurotransmitter in Guinea-Pig Gastric Antrum
- Kang, Tong-Mook (Department of Physiology, Sungkyunkwan University School of Medicine) ;
- Xu, Wenxie (Department of Physiology & Biophysics, Seoul National University College of Medicine) ;
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Kim, Sung-Joon
(Department of Physiology & Biophysics, Seoul National University College of Medicine) ;
- Ahn, Seung-Cheol (Department of Physiology & Biophysics, Seoul National University College of Medicine) ;
- Kim, Young-Chul (Department of Physiology & Biophysics, Seoul National University College of Medicine) ;
- So, In-Suk (Department of Physiology & Biophysics, Seoul National University College of Medicine) ;
- Park, Myoung-Kyu (Department of Physiology, Sungkyunkwan University School of Medicine) ;
- Uhm, Dae-Yong (Department of Physiology, Sungkyunkwan University School of Medicine) ;
- Kim, Ki-Whan (Department of Physiology & Biophysics, Seoul National University College of Medicine)
- 발행 : 1999.04.21
초록
We explore the question of whether adenosine 5'-triphosphate (ATP) acts as an excitatory neurotransmitter in guinea-pig gastric smooth muscle. In an organ bath system, isometric force of the circular smooth muscle of guinea-pig gastric antrum was measured in the presence of atropine and guanethidine. Under electrical field stimulation (EFS) at high frequencies (>20 Hz), NO-mediated relaxation during EFS was followed by a strong contraction after the cessation of EFS (a 'rebound-contraction'). Exogenous ATP mimicked the rebound-contraction. A known