생물정신의학 (Korean Journal of Biological Psychiatry)
- 제5권2호
- /
- Pages.278-282
- /
- 1998
- /
- 1225-8709(pISSN)
- /
- 2005-7571(eISSN)
심인성 발기부전 환자에서 Norepinephrine과 Serotonin에 관한 연구
Norepinephrine and Serotonin in the Patients with Psychogenic Impotence
- 김진세 (고려대학교 의과대학 정신과학교실) ;
- 유승호 (건국대학교 의과대학 정신과학교실) ;
- 문두건 (고려대학교 의과대학 비뇨기과학교실) ;
- 김제종 (고려대학교 의과대학 비뇨기과학교실) ;
-
정인과
(고려대학교 의과대학 정신과학교실)
- Kim, Jin Se (Department of Psychiatry, Korea University College of Medicine) ;
- Ryu, Seung Ho (Department of Psychiatry, Kon-Kuk University College of Medicine) ;
- Moon, Du Geon (Department of Urology, Korea University College of Medicine) ;
- Kim, Je Jong (Department of Urology, Korea University College of Medicine) ;
-
Jung, In Kwa
(Department of Psychiatry, Korea University College of Medicine)
- 발행 : 1998.12.25
초록
Various neurotransmitters have been proposed as possible mediators of penile erection. Especially, norepinephrine and serotonin might have a important role in sexual arousal and penile erection. And it could be hypothesized that the psychogenic impotence is associated with the depletion or imbalance of norepinephrine and serotonin from evidences, such as the symptomatic manifestation of depression and the antidepressantinduced sexual dysfunction. The authors investigates the association of norepienphrine and serotonin with psychogenic impotence. The psychogenic impotent group(PIG) consisted of twenty-three patients with psychogenic impotence and the controlled group(CG) consisted of twenty-seven patients without psychogenic impotence. PIG had no organic cause accounting for their erectile dysfunction. The Beck Depression Inventory(BDI) and the State-Trait Anxiety Inventory(STAI) were applied to each subject to assess mood, state anxiety(SA) and trait anxiety(TA). Plasma norepinephrine level from systemic blood and 5-hydroxyindoleacetic acid(HIAA) levels from 24-hours urine were measured in each subject. The mean score of BDI of PIG was significantly higher than that of CG(p=0.015). PIG had a tendency of higher TA compared with CG(p=0.054). And also SA was higher in PIG, but did not show significant difference(p=0.193). The level of norepinephrine was significantly lower in patient with psychogenic impotence(p=0.000). And the level of 24-hours urine 5-HIAA was lower in PIG but did not show significant difference(p=0.494). Although the authors did not exclude depressive disorders in PIG, the present findings suggest that psychogenic impotence might have higher depressive mood and trait anxiety, and be associated with the depletion of norepinephrine in systemic blood.