Calcium carbonate 및 자가골 이식술을 동반한 조직유도재생술후 생검을 통한 재생골의 조직학적 관찰

Histologic observation of regenerated bone in human intraosseous lesion following guided tissue regeneration with calcium carbonate implant and autogenous bone graft

  • 이용무 (서울대학교 치과대학 치주과학교실 및 치학연구소) ;
  • 한수부 (서울대학교 치과대학 치주과학교실 및 치학연구소) ;
  • 엄흥식 (강릉대학교 치과대학 치주과학교실) ;
  • 김동균 (서울대학교 치과대학 치주과학교실 및 치학연구소)
  • Lee, Yong-Moo (Department of Periodontology and Dental Research Institute, College of Dentistry, Seoul National University) ;
  • Han, Soo-Boo (Department of Periodontology and Dental Research Institute, College of Dentistry, Seoul National University) ;
  • Um, Heung-Sik (Department of Periodontology, College of Dentistry, Kannung National University) ;
  • Kim, Dang-Kyoon (Department of Periodontology and Dental Research Institute, College of Dentistry, Seoul National University)
  • 발행 : 1998.06.30

초록

For histologic observation of the regenerated bone following guided tissue regeneration (GTR) using ePTFE membranes with calcium carbonate implant and autogenous bone graft, biopsies were collected from 2 patients during 5-year-postoperative surgical reentry. In both combined cases with guided tissue regeneration in conjunction with calcium carbonate implant and autogenous bone graft, significant bone fill and gain in probing attachment level was observed. In histologic examination, specimen in GTR case with calcium carbonate grafting was composed of a dense bone containing vascular channel with lamellar structure and viable bone cells in lacunae, however considerable calcium carbonate particles remained unresorbed and isolated from regenerated bone by the dense cellular and fibrous connective tissue. No formative cells could be seen in contact with remained calcium carbonate particles. In GTR case with autogenous bone grafting, specimen show was composed of a dense lamellar bone containing vascular channel, which showed normal alveolar bone architectures. The present observation indicate that guided tissue regeneration in conjunction with grafting, especially autogenous bone graft, has highly osteogenic potential, however resorbable calcium carbonate granules were not completely resorbed at 5 year postimplantation.

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