Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Antigenicity of Intralipidos in Guinea Pigs, Mice and Rats

기니픽, 마우스 그리고 랫드에서 Intralipidos의 항원성

  • Yi, Beoung-Hi (Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University) ;
  • Che, Jeong-Hwan (Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University) ;
  • Li, Guang-Xun (Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University) ;
  • Kang, Byeong-Cheol (Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University) ;
  • Lee, Won-Woo (Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University) ;
  • Ihm, Jong-Hee (Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University) ;
  • Jung, Ji-Youn (Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University) ;
  • Lee, Yong-Soon (Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University)
  • 이병희 (서울대학교 수의과대학 공중보건학교실) ;
  • 제정환 (서울대학교 수의과대학 공중보건학교실) ;
  • 이광훈 (서울대학교 수의과대학 공중보건학교실) ;
  • 강병철 (서울대학교 수의과대학 공중보건학교실) ;
  • 이원우 (서울대학교 수의과대학 공중보건학교실) ;
  • 임종희 (서울대학교 수의과대학 공중보건학교실) ;
  • 정지윤 (서울대학교 수의과대학 공중보건학교실) ;
  • 이영순 (서울대학교 수의과대학 공중보건학교실)
  • Published : 1998.09.01
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Abstract

The antigenicity of intralipidos was investigated in guinea pig, mice and rats. Antigenicity tests-active systemic anaphylaxis (ASA), passive systemic anaphylaxis (PSA), passive cutaneous anaphylaxix (PCA) of this materials were performed. The results were followed: 1. After sensitizaion with YPL, YPL+intralipidos, and intralipidos, emulsified with complete Freund's adjuvant (CFA), guinea pigs didn's show any anaphylatic shock symptom in the ASA test, 2. These materials didn't show any anaphylatic shock symptom in the PSA test, 3. After sensitization with antisera of YPL, YPL+intralipidos, and intralipidos sensitized mice, blue spots were not observed on the hypodermis of back of rats in the PCA test. From the results of this investigation, the antigenicity of YPL, intralipidos was negative under the present experimental condition.

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