YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Activation of Macrophages by GLB, a Protein-polysaccharide of the Growing Tips of Ganoderma Lucidum

영지버섯 생장점 단백다당체 GLB의 대식세포 활성화 효과

  • Oh, Jung-Yeon (Laboratory of Microbial Chemistry, College of Pharmacy, Chung-Nam National University) ;
  • Cho, Kyung-Joo (Laboratory of Microbial Chemistry, College of Pharmacy, Chung-Nam National University) ;
  • Chung, Soo-Hyun (Laboratory of Microbial Chemistry, College of Pharmacy, Chung-Nam National University) ;
  • Kim, Jin-Hyang (Laboratory of Microbial Chemistry, College of Pharmacy, Chung-Nam National University) ;
  • Lillehoj, H.S. (Protozoan Diseases Laboratory, Livestock and Poultry Sciences Institute, Agricultural Research Service) ;
  • Chung, Kyeong-Soo (Laboratory of Microbial Chemistry, College of Pharmacy, Chung-Nam National University)
  • 오정연 (충남대학교 약학대학 미생물약품화학교실) ;
  • 조경주 (충남대학교 약학대학 미생물약품화학교실) ;
  • 정수현 (충남대학교 약학대학 미생물약품화학교실) ;
  • 김진향 (충남대학교 약학대학 미생물약품화학교실) ;
  • ;
  • 정경수 (충남대학교 약학대학 미생물약품화학교실)
  • Published : 1998.06.01
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Abstract

In the previous study we described the antitumor activity of GLB, a protein-polysaccharide fraction of the growing tips of Ganoderma lucidum, against sarcoma 180 solid tu mor in ICR mice. In this study we investigated the stimulatory activity of GLB on macrophages. When analyzed using a flow cytometer, GLB ($100{\mu}g/ml$) was found to increase the phagocytic activity of the BALB/c mouse peritoneal macrophages as well as chicken macrophage BM2CL cells against FITC-labeled C.albicans by 55.2% and 21.2%, respectively. GLB also increased the spreading and the expression of MHC class II molecules of BM2CL cells as well as the mouse peritoneal macrophages. From these results, it is clear that GLB is a strong stimulator to the macrophages.

Keywords

References

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