약학회지 (YAKHAK HOEJI)
- 제42권6호
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- Pages.567-571
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- 1998
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
청피에 함유된 복강 마크로파지의 탐식작용 억제 성분
A Suppressive Component on Phagocytosis of Murine Peritoneal Macrophage in Aurantii immaturi pericarpium
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Eun, Jae-Soon
(College of Pharmacy, Woosuk University) ;
- Kim, Dae-Keun (College of Pharmacy, Woosuk University) ;
- So, June-No (College of Natural Science, Woosuk University) ;
- Zee, Ok-Pyo (College of Pharmacy, Sung Kyun Kwan University)
- 발행 : 1998.12.01
초록
The phagocytic activity of murine peritoneal macrophage, was determined by lucigenin chemiluminescence and engulfment of fluorescein-conjugated E. coli particle. The acti vity-guided fractionation upon the methylenechloride fraction of Aurantii immaturi pericarpium led to the isolation of a flavonoid, isosinensetin, as a suppressive component of phagocytosis. Isosinensetin suppressed the lucigenin chemiluminescence and the engulfment of fluorescein-conjugated E. coli particles and enhanced the production of nitric oxide in murine peritoneal macrophage.
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