YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Coffee Consumption During Pregnancy in Korean and Effect upon Serum Lipids Level in Maternal and Umbilical Cord Blood

우리나라 여성의 임신 중 커피 음용 실태와 산모혈 및 제대혈 중 지질치 변화에 미치는 영향

  • Published : 1998.08.01
Download PDF
⟨ Previous Next ⟩

Abstract

To investigate the effect of coffee consumption during pregnancy on serum lipids in maternal and infants` umbilical cord blood, 76 cases of newborn infants and women delivered o f a child who had delivered at hospital located in Chung-Ju city from Feb. 1, 1996 to Aug. 31, 1996 were studied. The gestational ages of cases were 37 to 42 weeks and the average maternal ages were $28.3{\pm}4.63$ years old without any other medical or obstetric problems. Infants` Apgar scores and birth weights were decreased by above 3 cups per day of coffee consumption during pregnancy. No relationships between coffee consumption during pregnancy and maternal serum lipid levels were observed. However, serum total cholesterol and LDL-cholesterol levels in infants` umbilical cord were significantly increased with increasing coffee consumption during pregnancy. In contrary to coffee consumption, alcohol drinking habits affected maternal serum lipid levels but not serum lipid levels in infants` umbilical cord blood. Coffee consumption during pregnancy increased caffeine concentration in infants` umbilical cord blood. These results suggest that caffeine from maternal consumption of coffee can easily pass to the fetus and significantly affect serum lipids levels in infants` umbilical cord blood rather than those in maternal blood.

Keywords

References

  1. N. Engl. J. Med. v.308 The Troms Heart Study; Does coffee raise serum cholesterol? Thell D. S.;Aneson E.;Forde D. H.
  2. N. Engl. J. Med. v.278 Effects of caffeine on plasma renin activity, catecholamine and blood pressure Robertson O.;Frolich J. C.;Carr R. K.;Watson J. T.;Hollifield J. W.;Shand D. G.;Oates J. A.
  3. Lancet v.341 Bladder cancer and coffee drinking Viscoli C. M.;Lachs M. S.;Horwitz R. I.
  4. Int. J. Cancer v.42 Reproductive variables, tobacco, ethanol, coffee and somatometry as risk factors for ovarian cancer Polychronopoulou A.;Tzonou A.;Hsieh C. C.
  5. N. Engl. J. Med. v.315 Coffee consumption and incidence of coronary heart disease Lacrox A. Z.;Mead L. A.;Liang K. L.;Thomas C. B.;Person T. A.
  6. N. Engl. J. Med. v.308 The arrhythmogenic effects of caffeine in human being Dobmeyer D. J.;Stine R. A.;Leier C. V.;Greenberg R.;Shard S. F.
  7. J. Reprod. Med. v.19 Caffeine: Its direct and indirect influence on reproduction Weathersbee P. S.;Ledge J. R.
  8. J. of Obstetrics and Gynecology v.140 Caffeine and the fetus. Is trouble brewing? Merry B. M.;Louis W.
  9. Pediatr. Res. v.10 Elimination after-transplacentally acquired caffeine in fullterm neonates Parsons W. D.;Aranda J. V.;Neims A. H.
  10. Am. J. Obstet. Gynecol. v.147 The effect of caffeine on placental and fetal blood flow in human pregnancy Kirkinen P.;Jouppila P.;Koivula A.;Vuori J.;Pukka M.
  11. Neurobehavioral Toxicology v.7 Maternal caffeine use. before, during and after pregnancy and effects upon offspring Watkinson B.;Fried P. A.
  12. Seminars in Perinatology v.5 Caffeine ingestion during pregnancy: In Utero Exposure and Posible Effects Lester F.;Soyka M. D.
  13. Ann. Intern. Med(Nov) v.109 Caffeine and cardiovascular diseases Grobbee D. E.
  14. Am J Epidemiol. v.128 Coffee consumption and cholesterol in the hypertension detection and follow-up program Davis B. R.;Curb J. D.;Borhani N. O.;Prineas R. J.;Molteni A.
  15. Biol. Med. J. v.290 Coffee consumption and serum concentrations in men with hypercholesterolemia Forde O. H.;Knutsen S. F.;Arnesen E.;Thelle D. S.
  16. J. Clin. Epidemiol. v.48 The impact of changes in coffee consumption on serum cholesterol Wei M.;Macera C. A.;Hornung C. A.;Blair S. N.
  17. Am J Epidemiol. v.122 Alcohol consumption and high density lipoprotein cholesterol concentration among alcoholics Dai W. S.;Laporte R. E.;Hom D. L.;Kuller L. H.;Antonio J. A.;Gutei J. P.;Wozniczak M. B.
  18. Am J Epidemiol. v.123 Coffee, and serum cholesterol in Japanese in Hawaii Curb J. D.;Reed D. M.;Kautz J. A.;Yano K.
  19. Biol. Med. J. v.291 Coffee, tea, and plasma: The Jerusalem lipid research clinic prevalence study Kark, J. D.;Friedlomder Y.;Kaufmann N. A.;Stein Y.
  20. Clin. Pharmcol. Ther. v.25 Caffeine metabolism in newborn Aldridge A.;Sc B.;Aranda J. V.;Neims A. H.