Toxicological Research
- Volume 14 Issue 3
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- Pages.411-414
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- 1998
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- 1976-8257(pISSN)
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- 2234-2753(eISSN)
Acute Subcutaneous Toxicity of DWP-311 in Rats
랫드에 대한 DWP-311의 급성피하독성시험
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Kwack, Seung-Jun
(Division of Toxicology, School of Pharmacy, Sungkyunkwan University) ;
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Kim, Hyung-Sik
(Division of Toxicology, School of Pharmacy, Sungkyunkwan University) ;
- Chun, Sun-Ah (Division of Toxicology, School of Pharmacy, Sungkyunkwan University) ;
- Lim, So-Young (Division of Toxicology, School of Pharmacy, Sungkyunkwan University) ;
- Park, Hyun-Sun (Division of Toxicology, School of Pharmacy, Sungkyunkwan University) ;
- Han, Ha-Su (Division of Toxicology, School of Pharmacy, Sungkyunkwan University) ;
- Hong, Chae-Young (Division of Toxicology, School of Pharmacy, Sungkyunkwan University) ;
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Ahn, Mi-Young
(Division of Toxicology, School of Pharmacy, Sungkyunkwan University) ;
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Lee, Byung-Mu
(Division of Toxicology, School of Pharmacy, Sungkyunkwan University)
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곽승준
(성균관대학교 약학대학 독성학교실) ;
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김형식
(성균관대학교 약학대학 독성학교실) ;
- 천선아 (성균관대학교 약학대학 독성학교실) ;
- 임소영 (성균관대학교 약학대학 독성학교실) ;
- 박현선 (성균관대학교 약학대학 독성학교실) ;
- 한하수 (성균관대학교 약학대학 독성학교실) ;
- 홍채영 (성균관대학교 약학대학 독성학교실) ;
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안미영
(성균관대학교 약학대학 독성학교실) ;
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이병무
(성균관대학교 약학대학 독성학교실)
- Published : 1998.09.01
Abstract
The acute toxicity of DWP-311 was investigated in Sprague-Dawley rats. DWP-311 was subcutaneously administratered at dose levels of 595, 1,070, 1,930, 3,470, and 6,250mg/kg. In this study, we daily examined numbers of deaths, clinical signs, body weights, and pathological examinations for 7 days after administration of DWP-311. The results indicate that DWP-311 did not show any toxic effect in rats and the oral