대한바이러스학회지 (The Journal of Korean Society of Virology)
- 제28권2호
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- Pages.183-192
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- 1998
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- 1225-2344(pISSN)
스크래피에 감염된 마우스의 뇌 및 간조직에서의 DNA Methylation
DNA Methylation in Brain and Liver Tissues of Mice Infected with Scrapie Agent
- Choi, E.K. (Institute of Environment & Life Science and Department of Microbiology, School of Medicine, Hallym University) ;
- Uyeno, S. (Department of Radiation Research, Tohoku University School of Medicine) ;
- Ono, T. (Department of Radiation Research, Tohoku University School of Medicine) ;
- Carp, R.I. (Department of Virology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island) ;
- Kim, Y.S. (Institute of Environment & Life Science and Department of Microbiology, School of Medicine, Hallym University)
- 발행 : 1998.06.30
초록
DNA methylation degree in the several murine brain and liver genes of different ages and after scrapie infection have been examined by using methylation-sensitive restriction endonuclease digestion. We found that the methylation of c-fos and c-myc in the brain and liver was increased during the late fetal to one month postnatal developmental periods. However, those of the SGP-2,