Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Effects of Administration of 2,2'-Azobis(2-amidinopropane) Dihydrochloride(AAPH) on Liver Function in Rats 2. Serum Enzyme Activities

2,2'-Azobis (2- amidinopropane) dihydrochloride (AAPH)의 투여가 쥐의 간기능에 미치는 영향 2. 혈청 효소 활성치

  • 강정부 (경상대학교 수의과대학(동물의학연구소)) ;
  • 손호상 (경상대학교 수의과대학(동물의학연구소)) ;
  • 김철호 (경상남도 축산진흥연구소)
  • Published : 1998.03.01
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Abstract

This study was performed to determine the changes of serum enzyme activities in rats with hepatic injury induced by the administration of AAPH. Minor behavioral change, brittleness of skin hair and decreased water and fled intake were observed in rats administered intraperitoneally with AAPH. Serum AST and ALT activities pre-treatment were $65{\pm} 13.8 and 32{\pm}$ 12.6 IU/L, respectively and increased sharply from 2 hours of administration and reached $1248{\pm} 77.6 and 946{\pm}$ 45.6 IU/L, respectively at 48 hours of administration. Serum ALP and $\gamma -GTP activities pretreatment were 221 {\pm} 75.6 and 2.2{\pm}$ 0.35 IU/L respectively and increased sharply from 8 hours of administration and reached $767{\pm} 44.9 IU/L and 8.0{\pm} 1.23 IU/L,$ respectively at 48 hours of administration.

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References

  1. J Free Radic Biol Med v.1 no.1 Pathological mechanisms in carbon tetrachloride hepatotoxicity Brattin WJ;Glende EAJR;Recknagel RO
  2. J Pharmacol. Exp. Ther. v.134 Reduction of carbon tetrachloride in vivo and reduction of carbon tetrachloride and chloroform in vitro by tissues and tissue consituents Butler TC
  3. J Path Bacteriol v.85 Carbon tetrachloride poisoning in liver of the newborn rat Dawkius MJR
  4. Korean J Vet Clin Med v.14 no.2 사염화탄소$(CCl_{4})$의 투여가 쥐의 간기능에 미치는 영향 Ⅰ: 임상증상 및 혈액화학치 강정부;이은석;허주형
  5. Korean J Vet Clin Med v.14 no.2 사염화탄소$(CCl_{4})$의 투여가 쥐의 간기능에 미치는 영향 Ⅱ. 혈액효소활성치 강정부;이은석;허주형
  6. J clin pathol v.7 Estimation of plasma alkaline phosphate by oleteramination of hydrolysed phenol with amino-antipyrine Kind PRN;King EJ
  7. Clin Chem Acta v.26 A routine procedure for estimating serum gamma-glutamyl transpeptidase activity Naftalin L;Sexton M;Tracey D
  8. Chem Phys Lipids v.45 The role of lipid reroxidation in liver damage Poli G;Albano E;Dianzani MU
  9. Chem Biol Interac v.37 The role of lipid peroxidation in $(CCl_{4})$-induced damage to liver microsomal enzymes : Comparative studies in vitro usiry microsomes and isolated liver cells Poli G;Cheseman KH;Slater TF;Dianzani MU
  10. Exp Mol Pathol v.9 Early onset of lipoperoxidation in rat liver after carbon tetrachloride administration Rao KS;Recknagel RO
  11. Life sciences v.33 no.5 A new direction in the study of carbon tetrachloride hepatotoxicity Rechnagel RO
  12. Lab Invest v.25 Liver parenchymal cell injury Ⅶ : membrane denaturation following carbon tetrachloride Reynolds ES;Ree HJ
  13. Biochem Biophisica v.738 Neoplasmic progression in experimental hepatocarcinogenesis Sherer E
  14. Nature v.263 New principle for the analysis of chemical carcinogenesis Solt DB;Farber E
  15. J Free Radicals in Biol Med v.2 Damage to biological tissue induced by radical initiator 2,2'-azobis(2-amidinopropane) dihydrochloride and its inhibition by chain-breaking antioxidants Terao K;Niki E
  16. J Toxicol pathol v.2 Liver injuries induced by free radical Terao K