Archives of Pharmacal Research
- 제21권2호
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- Pages.179-186
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- 1998
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Synthesis and Properties of Dextran-5-amonosalicyclic Acid Ester as a Potential Colon-specific Prodrug of 5-Aminosalicyclic Acid
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Jung, Yun-Jin
(College of Pharmacy, Pusan National University) ;
- Lee, Jeoung-Soo (College of Pharmacy, Pusan National University) ;
- Kim, Hak-Hyun (College of Pharmacy, Pusan National University) ;
- Kim, Yun-Taek (College of Pharmacy, Pusan National University) ;
- Kim, Young-Mi (College of Pharmacy, Pusan National University)
- 발행 : 1998.04.01
초록
Dextran-5-aminosalicylic acid ester (dextran-5-ASA) was synthesized as a colon-specific prodrug of 5-aminosalicylic acid (5-ASA) which is active against inflammatory bowel diseases. Chemical stability of dextran-5-ASA in the bath of pH 1.2 or 6.8 was investigated at
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