Archives of Pharmacal Research
- 제21권2호
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- Pages.174-178
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- 1998
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Synthesis and Evaluation of 5-Aminosalicyl-glycine as a Potential Colon-specific Prodrug of 5-Aminosalicylic Acid
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Jung, Yun-Jin
(College of Pharmacy, Pusan National University) ;
- Lee, Jeoung-Soo (College of Pharmacy, Pusan National University) ;
- Kim, Hak-Hyun (College of Pharmacy, Pusan National University) ;
- Kim, Young-Mi (College of Pharmacy, Pusan National University) ;
- Han, Suk-Kyu (College of Pharmacy, Pusan National University)
- 발행 : 1998.04.01
초록
As a new colon-specific prodrug of 5-aminosalicylic acid (5-ASA), 5-aminosalicyl-glycine (5-ASA-Gly) was prepared by a simple synthetic route in good yield. Apparent partition coefficients of 5-ASA-Gly were lower than those of 5-ASA, which determined in
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