The effects of Sipjeondaebotanggamibang on anti-tumor chemotherapheutic cytotoxicity and lysosomal enzymes of tumor cell

십전대보탕가미방(十全大補湯加味方)이 항암화학요법제(抗癌化學療法劑)의 세포독성(細胞毒性) 및 종양세포(腫瘍細胞)의 lysosomal enzymes에 미치는 영향(影響)

  • Lee, Hyung-Ju (Department of Internal Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Jeon, Byung-Hun (Department of Pathology, College of Oriental Medicine, Wonkwang University) ;
  • Won, Jin-Hee (Department of Internal Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Moon, Gu (Department of Internal Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Moon, Seok-Jae (Department of Internal Medicine, College of Oriental Medicine, Wonkwang University)
  • 이형주 (원광대학교 한의과대학 내과학 교실) ;
  • 전병훈 (원광대학교 한의과대학 병리학교실) ;
  • 원진희 (원광대학교 한의과대학 내과학 교실) ;
  • 문구 (원광대학교 한의과대학 내과학 교실) ;
  • 문석재 (원광대학교 한의과대학 내과학 교실)
  • Published : 1998.08.30

Abstract

Mainly side effects of antitumor chemotheraphy are fatigue, G-Ⅰ trouble(such as vomitting, nausea, diarrhea) and reduction of medullary function etc. Differentiated from syndromes in oriental medicine, above symptoms are recognized to 'Deficiency of both ki(vital energy) and blood'. And SDT(Sipjeondaebotang) has been widely used in 'Deficiency of both ki(vital energy) and blood'. Dr. Mun's SDTG(Sipjeondaebotanggamibang) consists of SDT plus several herb medicines-these have antitumor effect and reduce chemotherapheutic side effect. This experiment was undertaken to study the effects of SDTG on chemotherapheutic side effect and cytotoxicity. The results obtained in this study were as follows: Antitumor activities of the ethanol extract from SDTG(Sipjeondaebotanggamibang) and MMC(Mytomycin) on ascitis form of calcinoma in mice is a little improved. Especialy mean survival times of the group of SDTG(200mg/kg) and MMC(0.1mg/kg) is improved over 50%. When SDTG and MMC is administrated together, the weight of tumor is more decreased than MMC alone. The effect of the ethanol extract from SDTG and MMC on the lysosomal enzymes in Ehrich ascites carcinoma cell are more significantly improved than MMC alone. SDTG extract increases both NKcell conjugation and cyto-lysis against target cell. According to the above results it is recognized that SDTG increases the chemotherapheutic cytotoxicity of MMC and the activity of NKcell.

Keywords

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