대한한방내과학회지 (The Journal of Internal Korean Medicine)

대한한방내과학회 (The Society of Internal Korean Medicine)
권호 표지

IL-1${\beta}$ 처리(處理) 당뇨병(糖尿病) 마우스의 췌장(膵臟) glucokinase 및 hexokinase 활성(活性)에 대(對)한 비파엽(枇杷葉)의 영향(影響)

Effect of Eriobotryae folium extract on glucokinase and hexokinase activities of diabetes mellitus mice induced by interleukin-$1{\beta}$

  • 윤철호 (동국대학교 한의과대학 내과학교실) ;
  • 신현철 (동국대학교 한의과대학 내과학교실) ;
  • 정지천 (동국대학교 한의과대학 내과학교실)
  • Yoon, Cheol-Ho (Department of Intenal Medicine, College of Orient Medicine, Dongguk University) ;
  • Shin, Hyeon-Chul (Department of Intenal Medicine, College of Orient Medicine, Dongguk University) ;
  • Jeong, Ji-Cheon (Department of Intenal Medicine, College of Orient Medicine, Dongguk University)
  • 발행 : 1998.08.30
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초록

We investigated the in vivo effect of an aqueous extract (referred to as EF) from Eriobotryae folium on glucokinase and hexokinase activities of diabetes mellitus induced by $interleukin-1{\beta}\;(IL-1{\beta})$. After 1 week of $IL-1{\beta}$ injection, the levels of serum glucose concentration and insulin secretion were dramatically increased. However, the insulin secretion was decreased with administration of EF. The level of glucose concentration was decreased by EF administration. Furthermore, it was observed that EF was effective in recovering the levels of insulin secretion. Enzyme activities of the glucokinase and hexokinase, which are key enzymes of glucose phosphorylastion, were decreased by $IL-1{\beta}$. EF administration to the mice allowed proportional increasing by stimulation of induction of enzyme activities as high as normal group. These results suggested that EF is highly effective in treatment of diabetes mellitus induce by $IL-1{\beta}$.

키워드

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