생약학회지 (Korean Journal of Pharmacognosy)

  • 제29권4호
  • /
  • Pages.283-292
  • /
  • 1998
  • /
  • 0253-3073(pISSN)
  • /
  • 2288-9299(eISSN)
한국생약학회 (The Korean Society of Pharmacognosy)
권호 표지

녹혈이 Cyclophosphamide로 유도된 악성빈혈의 조혈기능 촉진에 미치는 영향

Hemopoietic Effects of Deer Blood on Cyclophosphamide Induced Pernicious Anemia

  • 홍순복 (한국한의학연구원 연구부) ;
  • 김은해 (한국한의학연구원 연구부) ;
  • 마진열 (한국한의학연구원 연구부) ;
  • 은영아 (한국한의학연구원 연구부) ;
  • 김한섭 (백운당한의원) ;
  • 박갑주 (한국한의학연구원 연구부)
  • Hong, Soon-Bok (Department of Research, Korea Institute of Oriental Medicine) ;
  • Kim, Eun-Hae (Department of Research, Korea Institute of Oriental Medicine) ;
  • Ma, Jin-Yeul (Department of Research, Korea Institute of Oriental Medicine) ;
  • Eun, Young-Ah (Department of Research, Korea Institute of Oriental Medicine) ;
  • Kim, Han-Seob (Baek Woon Dang Oriental Clinical Center) ;
  • Park, Kap-Joo (Department of Research, Korea Institute of Oriental Medicine)
  • 발행 : 1998.12.30
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초록

The hemopoietic effects of deer blood (whole blood, blood cell, plasma, respectively) were examined using in vivo rat model. Experimental animals (Sprague-Dawley rat, male, 200 g) were divided into negative control group (injection of saline), positive control group (injection of Sipjeondaebotang) experimental groups (injection of whole blood, blood cell, plasma) and healthy control group. Cyclophosphamide(150mg/kg) was injected into experimental groups, negative and positive control group to induce bone marrow supression. After 8 days, freez dried deer blood (whole blood, blood cell, plasma respectively) and Sipjeondaebotang of 200 mg/kg in dose was administered orally into experimental groups and positive control group, once a day for 3 days (A group) and once a day for 12 days (B group) respectively. And then body weight and organ weight, biochemical profile (ALB, GOT, GPT, PRO, CRE), hematological values (WBC, RBC, HGB, HCT, MCV, MCH, MCHC, PLT) and CBC differentiation (Neutro, Lymph, Mono, Reticulo) were carried out. Finally, platelets were specially increased in the plasma treated A group and reticulocytes were specially increased in the plasma treated B group.

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