Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Studies on Combined Usage of Velvet Antler Water Extract and Anti-neoplastic Drugs (I) -Reducing Effect of Velvet Antler Water Extract to the Adverse Actions of cis-Platin and Mitomycin C-

녹용 물추출물과 항암제의 병용투여에 관한 연구(제 1보) -녹용 물추출물과 cis-Platin 및 Mitomycin C 병용투여에 의한 항암제 부작용 경감효과-

  • Sim, Sang-Bum (East-West Medical Research Institute, Kyung Hee University) ;
  • Kim, Jae-Kun (Korea Food and Drug Administration) ;
  • Won, Do-Hee (Korea Food and Drug Administration) ;
  • Hong, Nam-Doo (Natural Product Research Institute of Bangchon, Hankooksinyak) ;
  • Kim, Nam-Jae (East-West Medical Research Institute, Kyung Hee University)
  • 심상범 (경희대학교 동서의학연구소) ;
  • 김재근 (식품의약품안전청) ;
  • 원도희 (식품의약품안전청) ;
  • 홍남두 ((주)한국신약 방촌천연물연구소) ;
  • 김남재 (경희대학교 동서의학연구소)
  • Published : 1998.06.30
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Abstract

In order to investigate the reducing effect of velvet antler water extract (VAWE) on the toxicity of anti-cancer drug, cis-platin (CDDP) and mitomycin C (MMC), we examined effects of co-administration with VAWE and anti-cancer drugs on their toxicities. We recognized that $LD_{50}$ of CDDP/MMC were increased by co-administration with VAWE and them in mice. It was found that co-administration of VAWE and MMC increased the survival rate in mice treated by lethal dose of MMC. Also, co-administration of VAWE and CDDP/MMC inhibited decrease of the body weight and organ weight in mice intoxificated by CDDP/MMC. The increase of serum blood urea and serum creatinine levels in rats intoxicated by CDDP were significantly inhibited by the co-administrationin with VAWE and CDDP. The decrease of RBC and WBC in rats intoxificated by MMC were significantly inhibited by the co-administration with VAWE and MMC. These results suggest that the combined usage of VAWE and CDDP/MMC drugs may be a new method for prevented or minimized the toxicity of them.

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