The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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The Experimental Studies on the Anti-Stress Effects of Danchisoyosan(丹梔逍遙散)

단치소요산(丹梔逍遙散)의 항(抗)스트레스 효과(效果)에 대한 실험적(實驗的) 연구(硏究)

  • Shim, Mun-Ki (Dept. of Internal Medicine, College of Oriental Medicine Kyungwon University) ;
  • Park, Se-Ki (Dept. of Internal Medicine, College of Oriental Medicine Kyungwon University) ;
  • Kim, Dong-Woo (Dept. of Internal Medicine, College of Oriental Medicine Kyungwon University) ;
  • Han, Yang-Hee (Dept. of Internal Medicine, College of Oriental Medicine Kyungwon University) ;
  • Chun, Chan-Yong (Dept. of Internal Medicine, College of Oriental Medicine Kyungwon University) ;
  • Park, Chong-Hyeong (Dept. of Internal Medicine, College of Oriental Medicine Kyungwon University)
  • 심문기 (경원대학교 한의과대학 내과학교실) ;
  • 박세기 (경원대학교 한의과대학 내과학교실) ;
  • 김동우 (경원대학교 한의과대학 내과학교실) ;
  • 한양희 (경원대학교 한의과대학 내과학교실) ;
  • 전찬용 (경원대학교 한의과대학 내과학교실) ;
  • 박종형 (경원대학교 한의과대학 내과학교실)
  • Published : 1998.12.01
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Abstract

This study was aimed to evaluate the anti-stress effect of danchisoyosan on the rats stressed by immobilization. The experimental animals were immobilized in the stress box($5{\times}5{\times}20cm$) for 12 hours in a day during 3 days, and administered $500mg/5m{\ell}/g$ of Danchisoyosan extract for 14 days before stress. There were measured the change of body weight and organ weight under immobilized-stress. The norepinephrine, epinephrine, dopamine, serotonine contents were measured by HPLC method in rat brain. There were measured the GOT, GPT contents in serum and tissue lipid peroxidation in the brain, liver, spleen, adrenalgland, pancreas, testes, thymus, heart. The following results were obtained: 1. The change of organ weight was significantly lower in control than normal group. Sample group inhibited decreased weight from stress comparing to control group. 2. Lipid peroxidation in the liver was significantly higher in control than normal group. Sample group shows significant decrease comparing to control group. 3. Lipid peroxidation in the kidney was significantly higher in control than normal group. Sample group shows significant decrease comparing to control group. 4. GPT contents in serum was significantly higher in control than normal group. Sample up shows significant decrease comparing to control group. 5. Dopamine contents in the brain was significantly higher in control than normal group. Sample group shows significant decrease comparing to control group. 6. Serotonine contents in the brain was significantly higher in control than normal group. Sample group shows significant decrease comparing to control group.

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