Journal of the Korean Wood Science and Technology
- Volume 26 Issue 4
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- Pages.78-85
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- 1998
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- 1017-0715(pISSN)
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- 2233-7180(eISSN)
Antifungal Activity of the Extracts of Zanthoxylum Schinifolium Sieb. et Zucc. against Dermatophytes
산초나무 추출물의 피부사상균에 대한 항균활성과 그 성분
- Min, Kyeong-Heui (Forestry Research Institute)
- 민경희 (임업연구원)
- Received : 1998.09.22
- Published : 1998.12.30
Abstract
The antifungal activity of methanol extracts against dermatophytes was the highest at root-bark methanol extract, and the highest inhibitory effect was revealed in petroleum ether fraction of root-bark methanol extract. Compound I and compound II with significant antifungal activity were isolated from the fractions by silica gel column chromatography. As a result of the instrumental analyses, compound I and compound II were already known alkaloids. Compound I was identified as 4-methoxyfuro[2,3-6]quinoline (dictamnine ;
산초나무 각 부위별 알코올추출물의 피부사상균에 대한 항균활성은 근피 추출물에서 가장 높게 나타났으며, 각 용매별 분획분의 항균활성은 근피부의 petroleum ether 분획에서 가장 높게 나타났다. 항균활성성분을 분리하기 위해 항균력이 가장 높게 나타난 근피알코올추출물의 petroleum ether 분획분을 silica gel column chromatography를 실시하였으며, 항균활성성분인 CI과 CII가 분리되었다. CI과 CII의 MIC을 측정한 결과 CI의 MIC은
Keywords
- Zanthoxylum schinifolium;
- antifungal activity;
- alkaloid;
- 4-methoxyfuro[2,3-6]quinoline;
- dictamnine;
- 4-methoxy-1-methyl-2(1H)-quinolinone