• Title/Summary/Keyword: 4-methoxyfuro[2,3-6]quinoline

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Antifungal Activity of the Extracts of Zanthoxylum Schinifolium Sieb. et Zucc. against Dermatophytes (산초나무 추출물의 피부사상균에 대한 항균활성과 그 성분)

  • Min, Kyeong-Heui
    • Journal of the Korean Wood Science and Technology
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    • v.26 no.4
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    • pp.78-85
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    • 1998

  • The antifungal activity of methanol extracts against dermatophytes was the highest at root-bark methanol extract, and the highest inhibitory effect was revealed in petroleum ether fraction of root-bark methanol extract. Compound I and compound II with significant antifungal activity were isolated from the fractions by silica gel column chromatography. As a result of the instrumental analyses, compound I and compound II were already known alkaloids. Compound I was identified as 4-methoxyfuro[2,3-6]quinoline (dictamnine ; $C_{12}H_9NO_2$) and compound II was identified as 4-methoxy-lmethyl-2(1H)-quinolinone ($C_{11}H_{11}NO_2$). The MIC of compound I against T. mentagrophytes and T. rubrum was $40{\mu}g/m\ell$ and the MIC of compound II against the same fungi was $800{\mu}g/m\ell$.

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