Korean Journal of Veterinary Research (대한수의학회지)
- Volume 37 Issue 2
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- Pages.321-330
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- 1997
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- 2466-1384(pISSN)
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- 2466-1392(eISSN)
Serum bactericidal activity and disposition kinetics of enrofloxacin in Korean native goats
한국재래산양에서 Enrofloxacin의 혈청내 항균효과와 체내동태
- Yun, Hyo-in (Department of Veterinary Pharmacology & Toxicology, College of Veterinary Medicine, Chungnam National University) ;
- Kim, Moo-youl (Research Lab, Dae Sung Microbiologicals, Co., Ltd.) ;
- Park, Seung-chun (Department of Veterinary Pharmacology & Toxicology, College of Veterinary Medicine, Chungnam National University)
- Received : 1997.03.11
- Published : 1997.06.25
Abstract
Enrofloxacin is one of the second-generation quinolones which have been widely used to treat bacterial infections in various species including chicken, pig, horse and cattle. The objective of the present study was to describe the serum bactericidal activity(SBA) of enrofloxacin, its pharmacokinetic behaviors after intramuscular or intravenous administration to Korean native goats in the dose rate of 5mg/kg b.w. The results obtained through this study were as follows : 1. Sera collected from both sexes of Korean native goats administered 5mg/kg i.v. or i.m. showed potent antibacterial activities up to the 12 hours by way of the serum bactericidal activity. 2. Concentrations of enrofloxacin in the biological samples were measured by high-performance liquid chromatography(HPLC) so as to study pharmacokinetic characteristics. For detection of enrofloxacin, 10% TCA was optimal for protein precipitation and the mobile phase was 0.01M citric acid/methanol/acetonitrile(7/2/1, pH 3.5) with solid phase being the