YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Nitric Oxide Generation from Peritoneal Macrophages by Human Chorionic Gonadotropin

사람 융모 성선 자극 호르몬에 의한 복강 대식세로로부터 산화질소의 발생

  • Published : 1997.06.01
Download PDF
⟨ Previous Next ⟩

Abstract

Human chorionic gonadotropin (hCG) is a placental hormone and is involved in maintenance of the corpus luteum during pregnancy. In the present study, effect of hCG on nitiric ox ide (NO) generation from peritoneal macrophage was examined. hCG ahd no effect on NO generation by itself, whereas recombinant interferon- ${\gamma}$ (rIFN-${\gamma}$) alone had modest activity. When hCG was used in combination with rIFN-${\gamma}$, there was a marked cooperative induction of NO generation in a dose-dependent manner. The optimal effect of hCG on NO generation was shown at 6 hr after treatment with rIFN-${\gamma}$. Furthermore, northern blot analysis of showed that hCG increased the expression of inducible NO synthase(iNOS) gene. These results suggest that hCG induces NO generation from macrophages by increasing the expression of iNOS gene.

Keywords

References

  1. Neuron v.8 Nitric oxide a novel neouronal messenger Bredt, D. S.;Synder, S. H.
  2. Pharmacol. Rev. v.43 Nitric oxide: Physiology, pathophysiology, and pharmacology Moncada, S.;Palmer, R. M. J.;Higgs, E. A.
  3. Curr. Opinion Immunol. v.3 Role of nitric oxide synthesis in macrophage antimicrobial activity Nathan, C. F.;Hibbs, J. B. Jr.
  4. FASEB J. v.6 Nitric oxide as a secretory product of mammalian cells Nathan, C. F.
  5. Proc. Natl. Acad. Sci. USA v.82 Mammalian nitrate biosynthesis: Mouse macrophages produce nitrite and nitrate in response to Escherichia coli lipopolysaccharide Stuehr, D. J.;Marletta, M. A.
  6. Proc. Natl. Acad. Sci. v.78 Mammalian nitrate biosynthesis: Incorporation of $^{15}NH₃$ into nitrate is enhanced by endotoxin treatment Wagner, D. A.;Young, V. R.;Tannenbaum, S. R.
  7. J. Exp. Med. v.169 Activated murine macrophages secrete a metabolite of arginine with the bioactivity of endothelium-derived relaxing factor and the chemical reactivity of nitric oxide Stuehr, D. J.;Gross, S. S.;Sakuma, I.;Levi, R.;Nathan, C. F.
  8. Biochem. Biophys. Res. Commun. v.123 Iron depletion: possible cause of tumor cell cytotoxicity induced by activated macrophages Hibbs, J. B., Jr.;Taintor, R. R.;Vavrin, Z.
  9. Science v.235 Macrophage cytotoxicity: role for L-arginine deiminase and imino nitrogen oxidation to nitrite Hibbs, J. B., Jr.;Taintor, R. R.;Vavrin, Z.
  10. J. Exp. Med. v.169 A macrophage product responsible for eytostasis and respiratory inhibition in tumor target cells Stuehr, D. J.;Nathan, C. F.
  11. Annu. Rev. Biochem. v.50 Glycoprotein hormones: structure and function Pierce, J. G.;Parsons, T. F.
  12. Endocrinology v.119 Evidence for the presence of luteinizing hormone/human chorionic gonadotropin binding sites in the porcine uterus. Ziecik, A. J.;Stanchev, P. D.;Tilton, J. E.
  13. Proc. Soc. Exp. Biol. Med. v.189 Identification of LH/hCG receptors in rabbit uterus Jensen, J. D.;Odell, W. D.
  14. J. Physiol. Pharmacol. v.43 Extragonadal gonadotropin receptors. their distribution and function Ziecik, A. J.;Derecka-Reszka, K.;Rzucidlo, S. J.
  15. Endocrinology v.132 Novel expression of human chorionic gonadotropin/luteinizing hormone receptor gene in brain Lei, Z. M.;Rao, ChV.;Kornyei, J. L.;Licht, P.;Hiatt, E. S.
  16. Am. J. Physiol. v.269 Gonadotropin-stimulated regulation of blood-follicle barrier is mediated by nitric oxide Powers, R. W.;Chen, L.;Russel, P. T.;Larsen, W. J.
  17. Anal. Biochem. v.126 Analysis of nitrate, nitrite, and $[^{15}N]$ nitrate in biologic fluids Green, L. C.;Wagner, D. A.;Glogowski, J.;Skipper, P. L.;Wishnok, J. S.;Tannenbaum, S. R.
  18. Science v.256 Cloning and characterization of inducible nitric oxide synthase from mouse macrophages Xie, Q-W.;Cho H. J.;Calaycay, J.;Mumford, R. A.;Swiderek, K. M.;Lee, T. D.;Ding, A.;Troso, T.;Nathan, C.
  19. Dev. Brain Res. v.70 Localization and developmental expression of novel protein kinase C δ gene Kim, H. M.;Hirota, S.;Onoue, H.;Hirata, T.;Suzuki, K.;Ohno, S.;Kuroki, T.;Kitamura, Y.;Nomura, S.
  20. 대한산부인과학회지 v.36 융모성 성선자극호르몬이 생쥐대식세포 활성에 미치는 영향 최광은;김미란;권용일;유기성;정재근;남궁성은;이헌영;김승조
  21. J. Immunol v.154 Involvement of protein kinase C during Taxol-induced activation of murine peritoneal macrophages Jun, C. D.;Choi, B. M.;Kim, H. M.;Chung, H. T.
  22. Neuroimmunomodulation v.1 Phorbol ester synergistically increases interferon-γ-induced nitric oxide synthesis in murine microglial cells Yoon, H. J.;Jun, C. D.;Kim, J. M.;Rim, G. N.;Kim, H. M.;Chung, H. T.
  23. Biochem. Biophys. Res. Commun. v.204 Nitric oxide inhibits the expression of protein kinase C δ gene in the murine peritoneal macrophages Jun, C. D.;Choi, B. M.;Lee, S. Y.;Kang, S. S.;Kim, H. M.;Chung, H. T.
  24. Acta Endocrinol.(Copenh) v.129 Human chorionic gonadotropin binding sites in the human endometrium Bhattacharya, S.;Banerjee, J.;Sen, S.;Manna, P. R.
  25. J. Clin. Endocrinol. Metab. v.79 Expression of functional human chorionic gonadotropin/oluteinizing hormone receptor gene in human uterine arteries Toth, P.;Li, X.;Rao, ChV.;Lincoln, S. R.;Sanfilippo, J. S.;Spinnato, J. A.;Yussman, M. A.