YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Induction of Cd-binding High Molecular Weight Protein in Rat Tissues

흰쥐 조직에서의 카드뮴 결합 고분자량 단백질의 유도

  • 천기정 (한국원자력연구소 방사선응용그룹) ;
  • 김봉희 (충남대학교 약학대학) ;
  • Published : 1997.06.01
Download PDF
⟨ Previous Next ⟩

Abstract

The study was carried out on the biochemical characters of Cd-BP(I) after isolation and purification of the protein from the liver of rat injected intraperitoneally with Cd. A c ontinued study has been doing whether Cd-BP(I) could be induced by Cd or by other metals such as Zn and Cu. Antisera were made against the Cd-BP(I) from NewZealand white rabbits. Carried out were ${\gamma}$-globulin purification, then Ouchterlony test adn gel immunodiffusion test. Cd-BP(I) was also found in normal tissues of rat. It was induced up to a considerable level by Cd, whose induced level was higher than that of Cu or Zn treatment. The level of induction by Cu or Zn pretreatment plus Cd treatment was lower than that by simple treatment of Cu or Zn. Such a result was presumably related to the Cd toxicity.

Keywords

References

  1. Eur. J. Biochem v.118 Induction of metallothionein mRNA in HeLa cells by dexamethasone and by heavy metals Karin, M.;Anderson, R. D.;Herschman, H. R.
  2. Experientia Supplementum v.52 Toxicological significance of metallothionein Webb. M.
  3. Metallothionein J. H. R. Kagi(ed.);Y. Kojima(ed.)
  4. Toxicol. Appl. Pharmacol v.74 Zine-in-duced tolerance to cadmium hepatotoxicity. Goering, P. L.;Klaassen, C. D.
  5. Nature v.257 Cadmium resistance and content of cadmium-binding protein in cultured human cells Rugstad, H. E.;Norseth, T.
  6. Biochem. Pharmacol v.36 Cadmium-induced inhibition of protein secretion from liver: Pretreatment effect and specificity among cadmium. copper and zine Mitane, Y.;Aoki, Y.;Suzuki, K. T.
  7. Res. Commun. Chem. Pathol. Pharm. v.74 Different distribution of cadmium in the liver supernatant between in vivo and in vitro Sunaga, H.;Yamane, Y.;Aoki, Y.;Suzuki, K. T.
  8. Hunan Yike Daxue Xuebao v.17 Distribution of cadmium to blood components in rat. Tao, L.;Wang, X.
  9. Biologia v.46 Cadmium-binding proteins of digestive tract caterpillars of the species Galleria mellonella(Lepidoptera: Pyralidae) Polek, B.
  10. Appl. Pharmacol. v.106 Ethanol decreases cadmium hepatotoxicity in rats: possible role of hepatic metallothionein induction. Toxicol Kershaw, W. C.;Iga, T.;Klaassen, C. D.
  11. Yakhak Hoeji v.38 Isolation and purification of Cd-binding high molecular weight protein in rat liver(I) Chun, K. J.;Kim, B. H.
  12. Yakhak Hoeji Isolation and purification of Cd-binding high molecular weight protein in rat liver(II) Chun, K. J.;Kim, B. H.
  13. Anal. Biochem. v.72 A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding Bradford, M. M.
  14. Arch. Environ. Health. v.30 Cadmium accumulation in rat liver Colucci, A. V.;Winge, D.;Krasno, J.
  15. Environ. Physiol. v.1 Effects of acute and chronic cadmium exposure on the testicles of mice Nordberg, G. F.
  16. J. Reprod. Fertil v.15 Mechanisms of Zine, Cysteine and selenium protection against cadmium-induced vascular injury to mouse testis Gunn, S. A.;Gould, T. C.;Anderson, W. A. D.
  17. Chem. Pharm. Bull. v.25 Suppressive effect of zinc on the toxicity of mercury Yamane, Y.;Fukino, H.;Imagawa, M.
  18. Eisei Kagaku v.23 Substitution of Zinc bound to metallothionein for cadmium in vitro and in vivo Tanaka, K.;Onosaka, M. D.;Okahara, K.
  19. Toxicology v.40 Protection against cadmium toxicity by zinc: Decrease in the Cd-high molecular weight protein fraction in rat liver and kidney on Zn pretreatment Kudo, N.;Yamahshina, S.;Waku, K.
  20. Environ. Physiol. Biochem. v.5 Heavy metals in cadmium binding protein Sabbioni, C.;Marafante, E.
  21. Handbook on the toxicology of metals Cadmium Friberg, L.;jellstrom, T.;Nordberg, G.;Piscator, M.;L. Friberg(ed.);G. F. Nordberg(ed.);V. B. Vouk(ed.)