약학회지 (YAKHAK HOEJI)

  • 제41권5호
  • /
  • Pages.559-564
  • /
  • 1997
  • /
  • 0377-9556(pISSN)
  • /
  • 2383-9457(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

산오리나무의 세포독성 성분연구

Studies on the Cytotoxic Constituent of Alnus hirsuta$(S_{PACH})\;R_{UPR}$

  • 배춘일 (삼진제약(주) 중앙연구소) ;
  • 공재명 (삼진제약(주) 중앙연구소) ;
  • 오정완 (삼진제약(주) 중앙연구소) ;
  • 김현종 (삼진제약(주) 중앙연구소) ;
  • 오갑진 (삼진제약(주) 중앙연구소) ;
  • 박시경 (삼진제약(주) 중앙연구소) ;
  • 정순간 (삼진제약(주) 중앙연구소) ;
  • 조의환 (삼진제약(주) 중앙연구소)
  • Bae, Choon-Il (Central Research Institute, Samjin Pharmaceutical Co., LTD.) ;
  • Gong, Jae-Myung (Central Research Institute, Samjin Pharmaceutical Co., LTD.) ;
  • Oh, Jung-Wan (Central Research Institute, Samjin Pharmaceutical Co., LTD.) ;
  • Kim, Hyun-Jong (Central Research Institute, Samjin Pharmaceutical Co., LTD.) ;
  • Oh, Gab-Jin (Central Research Institute, Samjin Pharmaceutical Co., LTD.) ;
  • Park, Si-Kyung (Central Research Institute, Samjin Pharmaceutical Co., LTD.) ;
  • Chung, Sun-Gan (Central Research Institute, Samjin Pharmaceutical Co., LTD.) ;
  • Cho, Eui-Hwan (Central Research Institute, Samjin Pharmaceutical Co., LTD.)
  • 발행 : 1997.10.01
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초록

To find out antitumor active principles from natural resources, we have evaluated various extracts from the leaves of Alnus hirsuta (Betulaceae). The ethylacetate extract of this plant was found to show a significant cytotoxicity against several kinds of cultured human solid tumor cell lines (AGS, A5 49, HCT15, SKOV3, HEP3B) in vitro. Using cytotoxicity-guided chromatographic purification of the ethylacetate extract, cytotoxic constituent:1,7-bis-(4-hydroxyphenyl)-5-(${\beta}$-D-glucopyranosyloxy)-3-heptanone, was isolated and structurally identified by physico-chemical properties and spectroscopic evidences.

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참고문헌

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