YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Dose-dependent Antifibrotic Effect of Polysaccharide from Mycelium of Ganoderma Lucidum on Liver Biliary Cirrhosis in Rats

담도결찰 흰쥐에서 영지배양 균사체 유래 다당체의 항섬유화 효과 검색 및 용량의존성시험

  • Park, Eun-Jeon (Medicinal Resources Research Center, College of Pharmacy, Wonkwang University) ;
  • Ko, Geon-Il (Medicinal Resources Research Center, College of Pharmacy, Wonkwang University) ;
  • Kim, Jae-Baek (Medicinal Resources Research Center, College of Pharmacy, Wonkwang University) ;
  • Sohn, Dong-Hwan (Medicinal Resources Research Center, College of Pharmacy, Wonkwang University)
  • 박은전 (원광대학교 약학대학, 의약자원연구센터) ;
  • 고건일 (원광대학교 약학대학, 의약자원연구센터) ;
  • 김재백 (원광대학교 약학대학, 의약자원연구센터) ;
  • 손동환 (원광대학교 약학대학, 의약자원연구센터)
  • Published : 1997.04.01
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Abstract

This study was carried out to investigate the dose dependent antifibrotic effects of polysaccharide from mycelium of Ganoderma lucidum. The experimental hepatic cirrhosis was induced by bile duct ligation/scission (BDL/S) in rats. BDL/S rats in each group were dosed 0.5 mg, 2.0 mg, 5.0 mg or 10.O mg/rat/day orally for 4 weeks after the operation. Antifibrotic effects were evaluated by serum biochemical values, hydroxyproline contents, and light microscopical histology. The results obtained were as follows: 1) Hydroxyproline contents in liver of 5.0 and 10.0mg polysaccharide-treated BDL/S rats were significantly reduced 2) In serum test, ALT, AST, ALP values in polysaccharide from Ganoderma lucidum-treated group were lower than BDL/S control group 3) The hepatic damage such as hepatocellular necrosis, inflammation, bile duct proliferation and fibrosis was less severe in the livers of 2.0 mg and 5.0 mg polysaccharide-treated rats. These results suggest that polysaccharide from mycelium of Ganoderma lucidum to be a promising agent for the inhibition of hepatic cirrhosis.

Keywords

References

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