YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Studies on the Hypoglycemic Constituent of Pulsatillae Radix ( I )

백두옹의 혈당강하 성분연구 (I)

  • Kim, Hyun-Jong (Central Research Institute, Samjin pharmaceutical Co., LTD.) ;
  • Kim, Hyun-Tae (Central Research Institute, Samjin pharmaceutical Co., LTD.) ;
  • Bae, Choon-Il (Central Research Institute, Samjin pharmaceutical Co., LTD.) ;
  • Oh, Gapb-Jin (Central Research Institute, Samjin pharmaceutical Co., LTD.) ;
  • Park, Si-Kyung (Central Research Institute, Samjin pharmaceutical Co., LTD.) ;
  • Chung, Sun-Gan (Central Research Institute, Samjin pharmaceutical Co., LTD.) ;
  • Cho, Eui-Hwan (Central Research Institute, Samjin pharmaceutical Co., LTD.)
  • 김현종 (삼진제약(주) 중앙연구소) ;
  • 김현태 (삼진제약(주) 중앙연구소) ;
  • 배춘일 (삼진제약(주) 중앙연구소) ;
  • 오갑진 (삼진제약(주) 중앙연구소) ;
  • 박시경 (삼진제약(주) 중앙연구소) ;
  • 정순간 (삼진제약(주) 중앙연구소) ;
  • 조의환 (삼진제약(주) 중앙연구소)
  • Published : 1997.12.01
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Abstract

For the investigation of bioactive natural products with hypoglycemic effect, we have evaluated various extracts of Pulsatillae Radix(Ranunculaceae), which has been used in traditional medicine for hematochezia due to intense evil heat, malaria, chills and fever, epistaxis and internal hemorrhoids. The ethylacetate extract of the radix of this plant was found to show a significant hypoglycemic effect on alloxan diabetogenic mice. Using bioactivity-guided chromatographic purification of the ethylacetate extract, hypoglycemic constituent: 2${\beta}$, 3${\beta}$, 14${\alpha}$, 20, 22R, 25-hexahydroxy-cholest-7-en-6-one was isolated and structurally identified by physico-chemical properties and spectroscopic evidences.

Keywords

References

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