Pediatric Infection and Vaccine
- 제4권1호
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- Pages.126-132
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- 1997
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- 2384-1079(pISSN)
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- 2384-1087(eISSN)
1993년도 성남지역에서 유행한 홍역 환아에서의 홍역 특이 항체 반응
Response of Measles-specific Antibody in Children with Measles During Measles Epidemic in Seongnam, 1993
- 김지연 (인하대학교 의과대학 소아과학교실) ;
- 박윤형 (인하대학교 의과대학 소아과학교실) ;
- 김순기 (인하대학교 의과대학 소아과학교실) ;
- 최연화 (서울대학교 의과대학 소아과학교실) ;
-
이환종
(서울대학교 의과대학 소아과학교실) ;
- 손병관 (인하대학교 의과대학 소아과학교실)
- Kim, Ji Youn (Department of Pediatrics, College of Medicine, Inha University, Inha Hospital) ;
- Park, Yoon Hyung (Department of Pediatrics, College of Medicine, Inha University, Inha Hospital) ;
- Kim, Soon Ki (Department of Pediatrics, College of Medicine, Inha University, Inha Hospital) ;
- Choi, Yun Hwa (Department of Pediatrics, College of Medicine, Seoul National University) ;
-
Lee, Hoan Jong
(Department of Pediatrics, College of Medicine, Seoul National University) ;
- Son, Byong Kwan (Department of Pediatrics, College of Medicine, Inha University, Inha Hospital)
- 발행 : 1997.06.20
초록
목 적 : 높은 예방접종율에도 불구하고 흥역이 계속 발생하는 것은 1차 백신 실패 또는 2 차 백신 실패 등의 논란을 자아내고 있다. 이에 저자들은 1993년 전국적으로 홍역이 유행하였을 당시 인구 밀집 대도시인 성남지역에서 그 당시 홍역에 이환되었던 일부 소아를 대상으로 특이 혈청학적 검사를 실시하였다. 대상 및 방법 : 1993년 홍역이 유행할 당시 임상진단 기준에 따라서 홍역으로 진단된 초등학교생을 대상으로 학교에 의뢰하여 93년 12월 10일부터 5일간 채혈한 후, 혈청을 분리한 후
Measles outbreak in the world was decreased since measles vaccine had been introduced. Although vaccination rate is high, measles was not eradicated and measles reappeared among vaccinated children. We measured measles-specific antibody from the vaccinated and unvaccinated groups who had experienced apparent measles in the Seongnam city in 1993. The results were as follows. 1) The data included total 126 children (M:F=1 : 1). Age distribution of measles outbreak revealed 6 children in 5yr, 11 in 6yr, 20 in 7yr, 39 in 8yr, 22 in 9yr, 11 in 10yr, 11 in 11yr, and 6 in 12yr. 2) MMR vaccination rate was 78.6%(99/126) in the children who had experienced measles. Positive rate of measles-specific IgM Ab was 80.8% (80/99) among the vaccinated group and among 9E.6.% (25/27) the unvaccinated. 3) Positive rate of measles-specific IgG Ab was 90.9% (90/99) among MMR-vaccinated group, and 85.2% (23/27) in unvaccinated group. In conclusion, measles-specific IgM antibody have been detected more than 1 month in most patients. The relatively high proportion of measles-specific IgM positivity may mean primary vaccine failure. To booster the antibody titers and to prevent measles epidemic in school-aged children, revaccination of measles should be considered.