Journal of Microbiology and Biotechnology
- Volume 7 Issue 1
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- Pages.49-51
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- 1997
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- 1017-7825(pISSN)
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- 1738-8872(eISSN)
Antifungal Activities of Magainin-2 Hybrid Peptides against Trichosporon beigelii
- LEE, DONG GUN (Peptide Engineering Research Unit, Korea Research Institute of Bioscience and Biotechnology) ;
- SONG YUB SHIN (Peptide Engineering Research Unit, Korea Research Institute of Bioscience and Biotechnology) ;
- SUNG GU LEE (Peptide Engineering Research Unit, Korea Research Institute of Bioscience and Biotechnology) ;
- KIL LYONG KIM (Peptide Engineering Research Unit, Korea Research Institute of Bioscience and Biotechnology) ;
- MYUNG KYU LEE (Peptide Engineering Research Unit, Korea Research Institute of Bioscience and Biotechnology) ;
- KYUNG SOO HAHM (Peptide Engineering Research Unit, Korea Research Institute of Bioscience and Biotechnology)
- Published : 1997.02.01
Abstract
In order to obtain a hybrid synthetic peptide with a more potent antifungal activity than magainin-2 but without hemolytic activity, four hybrid peptides were designed from the sequences of magainin 2 and cecropin A and their antifungal activities against Trichosporon beigelii were investigated. The result showed that analogue 2 and 4 exhibited better antifungal activity against T. beigelii than magainin-2 but no hemolytic activities. The peptides, therefore, could be used as models for the development of potent antifungal peptides.