Pharmacological Actions of New Woohwangchungsimwon Liquid on Cardiovascular System

신우황청심원액의 심혈관계에 관한 약효연구

  • 조태순 (성균관대학교 약학대학) ;
  • 이선미 (성균관대학교 약학대학) ;
  • 김낙두 (서울대학교 약학대학) ;
  • 허인회 (중앙대학교 약학대학교) ;
  • 안형수 (동덕여자대학교 약학대학) ;
  • 박대규 (조선무약(주)생명과학연구소)
  • Published : 1997.12.01

Abstract

In order to investigate the pharmacological properties of New Woohwangchungsimwon Liquid (NCL), effects of Woohwangchungsimwon Liquid (CL) and NCL were compared. In isolated rat aorta, NCL and CL showed the relaxation of blood vessels in maximum contractile response to phenylephrine (10$^{-6}$ M) without regard to intact endothelium or denuded rings of the rat aorta. Furthermore, the presences of the inhibitor of NO synthase and guanylate cyclase did not affect the relaxation of NCL and CL. NCL and CL inhibited the vascular contractions induced by acetylcholine, prostaglandin endoperoxide or peroxide in a dose-dependent manner. In conscious spontaneously hypertensive rats (SHRs), NCL and CL significantly decreased heart rate. NCL and CL, at high doses, had a negative inotropic effect that was a decrease of LVDP and (-dp/dt)/(+dp/dt) in the isolated perfused rat hearts, and also decreased the contractile force and heart rate in the isolated rat right atria. In excised guinea-pig papillary muscle, NCL and CL had no effects on parameters of action potential at low doses, whereas inhibited the cardiac contractility at high doses. These results suggested that NCL and CL have weak cardiovascular effects with relaxation of blood vessels and decrease of heart rate, and that this effect is no significant differences between two preparations.

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