Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Pharmacological Actions of $\imath$--Muscone on Cardiovascular System

$\imath$--Muscone의 실험관계에 관한 약리연구

  • 조태순 (성균관대학교 약학대학) ;
  • 김낙두 (서울대학교 약학대학) ;
  • 허인회 (중앙대학교 약학대학) ;
  • 권광일 (충남대학교 약학대학) ;
  • 박석기 (조선무약(자)생명과학연구소) ;
  • 심상호 (조선무약(자)생명과학연구소) ;
  • 신대희 (조선무약(자)생명과학연구소) ;
  • 박대규 (조선무약(자)생명과학연구소)
  • Published : 1997.09.01
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Abstract

In order to investigate the pharmacological properties of ι-muscone, effects of ι-muscone and musk were studied on the cardiovascular system with various experimental models. In isolated rat aorta, ι-muscone and musk made the relaxation of blood vessels in maximum contractile response to phenylephrine (10$^{-6}$ M) in endothelium-containing rings of the rat aorta, but not in endothelium-denuded rings. However, ι-muscone and musk in the presence of the inhibitor of NO synthase and guanylate cyclase did not make the relaxation of blood vessels. In spontaneously hypertensive rats (SHRs), ι-muscone and musk slightly reduced blood pressure but significantly decreased heart rate. In the isolated perfused rat hearts, ι-muscone and musk did not affect significantly on LVDP, contractile force, coronary flow and (-dp/dt)/(+dp/dt). These results suggest that ι-muscone and musk have weak cardiovascular effects with relaxation of blood vessel and decrease of heart rate, but without significant cardiac functions.

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