한국식품위생안전성학회지 (Journal of Food Hygiene and Safety)
- 제12권4호
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- Pages.271-276
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- 1997
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- 1229-1153(pISSN)
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- 2465-9223(eISSN)
유기게르마늄(Ge-132)의 랫드와 마우스에 대한 급성경구독성
Acute toxicity of Organogermanium, Ge-132 in Rats and Mice
초록
The acute oral toxicity of organogermanium, Ge-132 was evaluated in rats andmice. The changes of body weight and clinical signs were observed for 14 days after the oral administration of Ge-132, from 0.31 g/kg up to 5 g/kg for SD rats and from 1.25 g/kg up to 5 g/kg for ICR mice. No death and toxic effects were observed for 14 days. The body weight of rats was significantly decreased 1 day after the administration in the maximum dosing group, but the decrease of body weight returned to control level 3 days after dosing. No significant changes in 132. Therefore, Ge-132 has no special toxic effects up to 5 g/kg, and LD* values of Ge-132 Ge-132 are above 5 g/kg in rats and mice.