Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Inhibition Effects of Zanthoxylum schinifolium and Its Active Principle on Lipid Peroxidation and Liver Damage in Carbon Tetrachloride-treated Mice

산초 및 그 활성성분이 사염화탄소를 부여한 Mouse에 있어서 지질과산화 및 간손상 억제에 미치는 영향

  • 문숙임 (동주여자전문대학 식품영양과) ;
  • 류홍수 (부경대학교 식품생명과학과) ;
  • 최재수 (부경대학교 식품생명과학과)
  • Published : 1997.10.01
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Abstract

The present study was undertaken to investigate the inhibition effects of sancho(Zanthoxylum schinifolium) on lipid peroxidation and liver damage in carbon tetrachloride tetracloride-treated mice. Mice aged 3 weeks old were fed diets containing either dry sancho powder, methanol extract or hyperoside isolated from sancho at the various levels for 2 weeks(sancho, methanol extract from sancho) or 3 days (hyperoside) before $CCl_{4}$ treatments. Seed coats of sancho added to diet with the levels from 1.25 to 5.0% significantly reduced(p<0.001) thiobarbituric acid reactive substances(TBARS) formation in liver and serum of mice treated with carbon tetrachloride. $CCl_{4}$ treatments significantly increased (p<0.001) in liver TBARS comparing with those of the untreated control, while methanol extract from the seed coat of sancho added to diet with the levels from 0.5 to 1.0% significantly reduced (p<0.01) to 20mg per kg of body weight showed significant reduction(p<0.01, p<0.001) of liver TBARS in mice treated with $CCl_{4}$. $CCl_{4}$ treatments significantly increased(p<0.05) in serum TBARS comparing with those the levels from 0.5 to 1.0% significantly reduced(p<0.01) serum TBARS in mice treated with $CCl_{4}$, and administration of hyperoside with the levels from 10 to 20mg per kg of body weight showed significant reduction(p<0.01, p<0.001) of serum TBARS in mice treated with $CCl_{4}$. $CCl_{4}$ significantly increased(p<0.001) in serum AST activities comparing with those of the untreated control, while either addition(0.5, 1.0%) of methanol extract from sancho or administration(10, 20mg/kg) of hyperoside significantly reduced(p<0.001, p<0.05) serum AST activities in $CCl_{4}$-treated mice. $CCl_{4}$ treatments showed significant increases(p<0.001) in serum ALT activities comparing with those of the untreated control, while either addition(0.5, 1.0%) of methanol extract from sancho or administration (10, 20mg/kg) of hyperoside showed moderate decreases(p<0.01, p<0.001) serum ALT activities in $CCl_{4}$-treated mice.

Keywords

References

  1. J. Am. Oil Chem. Soc. v.1 Toxicology and biochemistry of butylated hydroxyanisole and butylated hydroxytoluene Branen, A. S.
  2. Cancer Res. v.44 Dose-dependent reduction of N-2-fluorenylacetamide-induced liver cancer and enhancement of bladder cancer in rats by butylated hydroxytoluene Maeura, Y.;Weisburger, J. H.;Wiliams, G
  3. Agric. Biol. Chem. v.52 Antioxidative properties of proeyanidins B-1 and B-3 frin AZUKI beans in aqueous systems Koshiyama, A. T I.;Fukushima, D.
  4. JAOCS v.51 Antioxidant activity of tocopherols, ascorbyl palmitate, and ascorbic acid and their mode of action Cort, W. M.
  5. JAOCS v.61 Autoxidation of linoleic acid and behadvior of its hydroperoxides with and without tocopherols Koskas, J P;Cillard, J.;Cillard, P.
  6. J. Food Science v.50 Metabolites of Eurotium species, their antioxidative properties and synergism with tocopherol Ishikawa, Y.;Morimoto, K.;Hamasaki, T.
  7. J Food Sci v.55 Effects of α-, γ-, and δ-tocopherols on oxidative stability of soybean oil Jung, M Y.;Min, D B.
  8. J. Food Sci. v.56 α-, γ-, and δ-tocopherol effects on chlorophyll photosensitized oxidation soybean oil Jung, M Y.;Choe, E. O.;Min, D. B.
  9. Agric. Biol. Chem. v.55 Antioxidant effects of tocopherois and L-ascorbic acid on ethyl eicosapentaenoate and methyl linoleate Nishina, A.
  10. JAOCS v.62 Effect of ascorbyl palmitate on the quality of frying fats for deep frying operations Gwo, Y. Y.;Flick JR., G. J.
  11. J. Food Sci. v.55 Antioxidative effect of ascorbic acid solubilized in oils via reversed micelles Han, D.;Yi, O. S.;Shin, H. K.
  12. J. Food Sci. v.52 Effects of chlorophyll and β-carotene on the oxidation stability of olive oil Fakourelis, N.;Lee, E C.;Min, D. B.
  13. LIPIDS v.24 Antioxidant activity of β-Carotene-Related Carotenoids in solution Terao, J.
  14. Biosci. Biotech. Biochem. v.56 Antioxidative activity of amino acids and sulfur-containing compounds to superoxide : Measurement by quenching the chemilumescence of a Cypridina Luciferin analogue Suzuki, N.;Kochi, M;Wada, N.;Mashike, S.;Nomoto, T.;Yoda, B.
  15. Biochem. J. v.249 Polyamine inhibition of lipoperoxidation Tadolini, B.
  16. Proc. Natl. Acad. Sci. USA v.87 Antioxidant activity of carnosine, homocarnosine, and anserine present in muscle and brain Kohen, R.;Yamamoro, Y.;Cundy, K. C.;Ames, B. N.
  17. Proc. Natl. Acad. Sci. USA v.87 Antioxidant activities of some tryptophan metabolites. Possible implication for inflammatory diseases Christen, S.;Peterhans, E.;Stocker, R.
  18. J. Food Sci v.56 Isolation and partial characterization of natural antioxidant from shrimp(Pandalus jordani) Pasquel, L J. R;Babbitt, J. K.
  19. JAOCS v.51 Studies on antioxidant activity of tempeh oil Murata, G. K.;Sugimoto, Y.
  20. J. Food Sci. v.49 Antithiamin activity of polyphenolic antioxidants Yang, P. F.;Pratt, D. E.
  21. Bull. Jap. Soc. Sci. Fish. v.51 Screening for antioxygenic compounds in marine algae and bromophenols as effective principles in a red algae, Polysiphonia ulceolate Fujimoto, K.;Ohmura, H.;Kaneda, T.
  22. JAOCS v.68 Antioxidant effect of natural phenols on olive oil Papadopoulos, G.;Boskou, D.
  23. Biosci. Biotec. Biochem. v.56 Comparison of the antioxidative activity of some acid-phenols : Structure-activity relationship Cuvelier, M. E.;Richard, H.;Berset, C.
  24. J. Agric. Food Chem. v.40 Antioxidative substances in leaves of Polygonum hydropiper Haraguchi, H.;Hashimoto, K.;Yagi, A
  25. Kor. J. Pharmacogn. v.24 Screening for antioxidant activity of plants and marine algae and its active principles from Prunus davidiana Choi, J S.;Lee, J H.;park, H. J.;Kim, H. G.;Young, H. S.;Mun, S. I.
  26. Agric. Biol. Chem. v.53 Antioxidative activity of flavonoids from thyme(Thymus vulgaris L.) Miura, K;Nakatani, N
  27. JAOCS v.60 Relationship between fluorescence and antioxidant activity of ethanol extracts of Maillard browning mixture Park, C K;Kim, D. H.
  28. Cereal Sci. Today v.17 Compounds of browned flavor derived from sugar-amine reaction Hodge, J. E.;Millis, F. D.;Fisher, B. E.
  29. 한국식품과학회지 v.22 지방산의 산화에 대한 양조간장의 항산화 특성 최흥식;이정수;문갑순;박건영
  30. 한국식품과학회지 v.22 양조간장으로부터 항산화성 물질의 분리 및 그 특성 문갑순;최홍식
  31. J. Korean Soc. Food Nutr. v.22 Antioxidative characteristics of melanoidin related products fractionated from fermented soybean sauce Cheigh, H. S.;Lee, J. S;Lee, C. Y.
  32. J. Agric. Food Chem. v.31 Stability of antioxidants formed from histidine and glucose by the Maillard reactions Lingnert, H.;Waller, G. R.
  33. 부산수산대학 박사학위논문 Amino acid-xylose 갈변 반응물질의 항산화성 유병진
  34. 부산수산대학교 석사학위논문 어유 및 과산화어유를 섭취한 흰쥐에 있어서 플라보노이드 (+)-카테킨의 산화안정효과 권미나
  35. Bull. Chem. Soc. Japan v.41 Constituents of fruit oil from Japanese pepper Sakai, T.;Yoshihara, K.;Hirose, Y.
  36. 한국영양식량학회지 v.16 산초에 관한 연구 정현숙
  37. 부산여대논문집 v.제14집 산초지질의 지방산 조성에 관한 연구 심정숙;정옥희
  38. 경상대논문집(생농계편) v.22 산초지질성분의 계통적 분석 김명찬;조성환;김희숙;류충호
  39. 동의대학교 동의논집 v.제12집 산초나무 종자유와 몇가지 다른 종자유에 있어서의 필수지방산 조성 비교 강정옥
  40. 한양대학교 박사학위논문 한국산 초피와 산초의 과피 및 종자의 성분에 관한 연구 한희자
  41. 경희대학교 석사학위논문 한국산 산초의 지방질 조성에 관한 연구 한용도
  42. J. Jap. Soc. Food Nutr. v.26 Sterol composition of vegetables OKa, Y;KiriYama, S.;Yoshida, A.
  43. Research Reports of Agricultural Science and Technology v.3 Analytical studies on the composition of oil and protein in the seed of thornless Chinese pepper Zanthaxylum schinifolium var. inermis NAKAL Yoon, H. K.;Kim, C. M.
  44. 한사전문대 논문집 v.6 산초의 지방산 조성에 관한 연구 박명희
  45. 藥學雜誌 v.69 山椒の成分に仁추乙(1) 故淺野三千三
  46. 생약학회지 v.1 왕초피나무 Xanthoxylum coreanum NAKAL과피의 생약학적 연구(Ⅰ) 김홍선;류경수
  47. 藥學雜誌 v.71 山椒の成分に仁추乙(1) 相原傳
  48. 경희 약대논문집 v.3 산초류식물의 생약학적 연구 홍남두;김창민;류경수
  49. 경희 대학교 석사학위논문 산초 및 산초의 효능에 관한 실험적 연구 오한균
  50. J. Korean Soc. Food Nutr. v.23 Further screening for antioxidant activity of vegetable plants and its active principles from Zanthaxylum schinifolium Mun, S. I.;Ryu, H. S.;Lee, H. J.;Choi, J. S.
  51. J. Nutr. v.107 Ad. Hoc. Committee on standards for nutritional studies American Institute of Nutrition
  52. Anal. Biochem. v.95 Assay for lipid peroxide in animal tissues by thiobarbituric acid reaction Ohkawa, H.;Ohishi, N;Yaki, K.
  53. Am. J. Clin. Pathol. v.28 A colorimetric method for the determination of serum glutamic oxaloacetic and glutamic pyruvic transaminase Reitman, S.;Frankel, S.
  54. J. Clin Invst v.34 A note on the spectrophotometric assay of glutamic-oxaloacetic transaminase in human blood serum Karmen, A.
  55. Principles and procedures of statistics Steel, R. G. D.;Torrie, J. H.
  56. Alcohol v.25 Ethanol induced lipid peroxidation and oxidative stress in extrahepatic tissues Nordmann, R.;Ribierre, C.;Rouach, H.
  57. 한국영양식량학회지 v.22 미나리추출물이 사염화탄소에 의한 마우스 간손상에 미치는 영향 이상일;박용수;조수열
  58. 한국영양식량학회지 v.24 사염화탄소를 투여한 흰쥐에 있어서의 간기능에 미치는 칡 카테킨의 효과 한석현;김종배;민상기;이치호
  59. 한국영양식량학회지 v.18 사염화탄소로 인한 간 독성에 미치는 진달래(Rhododendron mucronulatum)화분의 영향 윤수홍;강정혜;권경숙
  60. 한국영양식량학회지 v.20 양파식이가 흰쥐에서 사염화탄소 독성에 미치는 영향 박평심;이병래;이명렬
  61. Pharmacol. Rev v.19 Carbon tetrachloride hepatotoxicity Reckinagel, R. O
  62. Biochem. Pharmacol. v.21 Effect of 3-methychloanthrene induction on the CCl-in-duced changes in rat hepatic microsomal enzyme system Maynard, E. H.;Bittern, S.;James, R G
  63. Mol. Pharmacol v.18 Metabolism of carbon tetrachloride in hepatic microsomes and deconstituted monooxygenase systems and its relationship to lipid peroxidation Wolf, C. R.;Willard, G. H Jr.;Wolfgang, M. N.;Richard, M. P.;Kalyanaraman, P. B.;Roland, P. M.
  64. 藥學雜誌 v.110 抗酸化 物質の實驗的肝腸害防護效果 鈴木眞;態澤紀子;太田節子;입川옥;숙田雅人
  65. 한국영양식량학회지 v.12 후추가 백서의 혈청 및 간장성분에 미치는 영향 조수열;이숙화
  66. Toxicology Applied Pharmacology v.99 The toxicity of flavonoids to guinea pig enterocytes Canada, A. T.;Watkins, W. D.;Nguyen, T. D.