Archives of Pharmacal Research

  • 제20권4호
  • /
  • Pages.313-317
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  • 1997
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  • 0253-6269(pISSN)
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  • 1976-3786(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

Inhibitory Effects of Plant Extracts on Adjuvant-induced Arthritis

  • 발행 : 1997.08.01
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초록

Twenty seven plant extracts were selected on the basis of ancient literature search for rheurnatoid arthritis or similar syndrome. Methanol extract of each plant was prepared and administered orally to rats everyday at a dose of 200 mg/kg/day. Experimental arthritis was induced by subplantar injection of heat-killed Mycobacterium butyricum to right hind paw of rats. This treatment provoked swelling of the treated paw in two phases, acute primary swelling and secondary arthritic swelling. An inhibition of secondary swelling was considered to be antiarthritic activity. Several plant methanol extracts such as Akebia quinata (caulis), Ephedla sinica (herba) and 5ophorae subprostratd (radix) were found to show significant inhibitory activity against secondary swelling at the dose tested. Our results strongly suggested an antiarthritic potential of these plant extracts.

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참고문헌

  1. Arthritis and Rheumatism v.36 Phospholipase $A_2$ and arthritis Bomalaski,J.S.;Clark,M.A.
  2. Planta Med. v.59 Anti-in-flammatory activity of resins of some species of the plant family Burseraceae Duwiejua,M.;Zeitlein,J.J.;Waterman,P.G.;Chapman,J.;Mhango,G.J.;Provan,G.J.
  3. J. Rheumatol. v.19 Inhibition of type II collagen-induced arthritis in mice by an immunosuppressive extract of Tripterygium wilfordii Hook f. Gu,W.Z.;Brandwein,R.;Banerjee,S.
  4. Chem. Pharm. Bull. v.24 Pericarp saponins of Akebia quinata Decne. I. Glycosides of hedragenin and oleanolic acid Higuchi,R.;Kawasaki,T.
  5. Chem. Pharm. Bull. v.24 Pericarp saponins of Akebia quinata Decen. II. Arjunolic and norarjunolic acid, and their glycosides Higuchi,R.;Kawasaki,T.
  6. J. Pharmacobiodyn. v.3 Anti-inflammatory principles of Aconitum roots Hikino,H.;Konno,C.;Takata,H.;Yamada,Y.;Yamada,C.;Ohizuma,Y.;Sugio,K.;Fujimura,H.
  7. Dong-Eu-Bo-Gam Huh,Z.
  8. Phytochem v.28 30-Noroleanane saponins from callus tissues of Akebia quinata Ikuda,A.;Itokawa,H.
  9. Kor, Biochem. News v.10 Glucocorticoids : Anti-inflammation and immunosuppression Kim,H.P.
  10. Chem. Pharm. Bull. v.32 Studies of scutellariae radix VII. Anti-arthritic and anti-inflammatory actions of methanolic extract and flavonoid components from scutellaria radix Kubo,M.;Matsuda,H.Tanaka,M.;Kimura,Y.;Okuda,H.;Higashino,M.;Tani,T.;Namba,K.;Arichi,S.
  11. Arch. Pharm. Res. v.18 Anti-inflammatory activity of the major constituents of Lonicera japonica Lee,S.J.;Shin,E.J.;Son,K.H.;Chang,H.W.;Kang,S.S.;Kim,H.P.
  12. Phytotherapy Res. Anti-inflammatory activity of Lonicera japonica Lee,S.J.;Son,K.H.;Chang,H.W.;Kang,S.S.;Kim,H.P.
  13. J. Biol. Chem. v.268 Differential inhibitor of prostaglandin endoperoxidase synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs Meade,E.A.;Smith,W.L.;Dewitt,L.
  14. Br. J. Pharmacol. v.21 Chemotherapy of arthritis induced in rats by mycobacterial adjuvant Newbould,B.B.
  15. J. Echnopharmacol. v.47 Anti-inflammatory activity of the bark of Hipporateaexcela Perez,R.M.;Perez,S.;Zavzla,M.A.;Salaza,M.
  16. Textbook of immunopharmacology Animal models for testing drugs on inflammatory and hypersensitivity reactions Sedgwick,A.D.;Willoughby,D.A.;Maureen Dale(ed.);Foreman(ed.)
  17. Phytochem v.35 Triterpenoid saponins from the aerial parts of Lonicers japonica Son,K.H.;Jung,K.Y.;Chang,H.W.;Kim,H.P.;Kang,S.S.
  18. Int. J. Immunopharmacol. v.15 Effect of a novel anti-rheumatic drug, TA-383, on type II collagen-induced arthritis-Suppressive effect of TA-383 on interleukin 6 production Sugita,T.;Ueno,M.;Furukawa,O,;Murakami,T.;Takata,I.;Tosa,T.
  19. Chinese drugs of plant origin Tang,W.;Eisenbrand,G.
  20. J. Pharm. Exp. Ther. v.178 Adjuvant-induced arthritis in rats. II. Drug effects on physiologic, biochemical and immunologic parameters Waltz,D.T.;Dimartino,M.J.;Misher,A.