Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Absolute Configuration of ${\beta}$-agarofuran nucleus of euojaponine C by CD exciton chirality method

  • Ryu, Jae-Ha (College of Pharmacy, Sookmyung Womens University) ;
  • Ryu, Shi-Yong (Korea Research Institute of Chemical Technology) ;
  • Han, Yong-Nam (Natural Products Research Institute, Seoul National University) ;
  • Han, Byung-Hoon (Natural Products Research Institute, Seoul National University)
  • Published : 1997.02.01
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Abstract

A new celastraceae alkaloid, euojaponine C has been isolated from the methanol extract of the root bark of Euonymus japonica. With the relative stereochemistry of euojaponine C established by NOESY data, the absolute stereochemistry has been determined by circular dichroism (CD) exciton chirality method. The CD of the 2, 5-bis-phenyl benzoate of triacetonide derived from the LiAlH$_{4}$, hydrolysate, euonyminol shows that the configuration of C-2 and C-5 are both R.

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