The Korean Journal of Physiology and Pharmacology
- 제1권6호
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- Pages.759-767
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- 1997
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- 1226-4512(pISSN)
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- 2093-3827(eISSN)
비-혈관평활근에서 새로운 $K^+$ 통로 개방제인 SKP-450의 약리학적 작용의 특성-Levcromakalim의 작용과 비교
In Vitro Pharmacological Characteristics of SKP-450, A Novel $K^+$ Channel Opener, in Non-Vascular Smooth Muscles in Comparison with Levcromakalim
- Park, Ji-Young (Department of Pharmacology, College of Medicine, Pusan National University) ;
- Kim, Hyun-Hee (Department of Pharmacology, College of Medicine, Pusan National University) ;
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Yoo, Sung-Eun
(Korea Research Institute of Chemical Technology) ;
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Hong, Ki-Whan
(Department of Pharmacology, College of Medicine, Pusan National University)
- 발행 : 1997.12.21
초록
In the present study, we characterized the non-vascular smooth muscle relaxant effects of a novel benzoyran derivative ,SKP-450 (2-[2'(1',3'-dioxolone)-2-methyl-4- (2'-oxo-1'-pyrrolidinyl) -6-nitro-2H-1- benzopyran) and its metabolite, SKP-310, in comparison with levcromakalim (LCRK). In the rat stomach fundus, the spontaneous motility stimulated by