The Korean Journal of Physiology and Pharmacology
- 제1권6호
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- Pages.769-774
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- 1997
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- 1226-4512(pISSN)
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- 2093-3827(eISSN)
기관근의 수축성에 대한 말초성 Benzodiazepine 수용체의 역할
Involvement of Peripheral Benzodiazepine Receptor on the Contractility of Canine Trachealis Muscle
- 류한영 (아주대학교 의과대학 흉부외과학교실) ;
- 최형철 (영남대학교 의과대학 약리학교실) ;
- 최은미 (영남대학교 의과대학 약리학교실) ;
- 손의동 (영남대학교 의과대학 약리학교실) ;
- 이광윤 (영남대학교 의과대학 약리학교실) ;
- 김원준 (영남대학교 의과대학 약리학교실) ;
- 하정희 (영남대학교 의과대학 약리학교실)
- Rhyu, Han-Young (Department of Chest Surgery, College of Medicine, Ajou University) ;
- Choi, Hyung-Cheol (Department of Pharmacology, College of Medicine, Yeungnam University) ;
- Choi, Eun-Mee (Department of Pharmacology, College of Medicine, Yeungnam University) ;
- Sohn, Uy-Dong (Department of Pharmacology, College of Medicine, Yeungnam University) ;
- Lee, Kwang-Youn (Department of Pharmacology, College of Medicine, Yeungnam University) ;
- Kim, Won-Joon (Department of Pharmacology, College of Medicine, Yeungnam University) ;
- Ha, Jeoung-Hee (Department of Pharmacology, College of Medicine, Yeungnam University)
- 발행 : 1997.12.21
초록
Non-neuronal high affinity binding sites for benzodiazepines have been found in many peripheral tissues including cardiac muscle and vascular smooth muscle, and have been designated as 'peripheral benzodiazepine receptor'. Benzodiazepines have been shown to induce relaxation of the ileal, vesical, and uterine smooth muscles. However, it is still unclear about possible involvement of peripheral benzodiazepine receptor on the contractility of trachealis muscle. This study was performed to investigate the role of the peripheral benzodiazepine receptor on the contractility of canine trachealis muscle. Canine trachealis muscle strips of 15 mm long were suspended in an isolated organ bath containing 1 ml of physiological salt solution maintained at