A Case of Rapid Cycling Secondary Mania after Gamma-knife Radiosurgery

감마나이프 방사선수술 후 발생한 급속 순환성 이차성 조증 1예

  • Chung, Chan-Ho (Keyo Hospital and Korean Neuropsychiatric Research Institute, Keyo Medical Foundation) ;
  • Chae, Jeong-Ho (Department of Psychiatry, Catholic University Medical College, Daejeon St. Mary's Hospital) ;
  • Kim, Im-Ryol (Keyo Hospital and Korean Neuropsychiatric Research Institute, Keyo Medical Foundation) ;
  • Lee, Chung-Kyoon (Keyo Hospital and Korean Neuropsychiatric Research Institute, Keyo Medical Foundation) ;
  • Lee, Kyu-Hang (Keyo Hospital and Korean Neuropsychiatric Research Institute, Keyo Medical Foundation)
  • 정찬호 (계요병원 및 한국신경정신의학연구소) ;
  • 채정호 (가톨릭대학교 의과대학 정신과학교실, 대전성모병원) ;
  • 김임렬 (계요병원 및 한국신경정신의학연구소) ;
  • 이정균 (계요병원 및 한국신경정신의학연구소) ;
  • 이규항 (계요병원 및 한국신경정신의학연구소)
  • Published : 1996.12.25

Abstract

A case of rapid cycling mania secondary to gamma-knife radiosurgery for the treatment of refractory epilepsy was reported. A 21-year old woman who had a gamma-knife radiosurgical operation for the treatment of refractory seizure two years ago was admitted because of manic episodes. Although seizure was relieved, manic symptoms like decreased need for sleep, elated mood, unprovoked laughing, grandiose delusion and bizarre behaviors were developed 11 months after the operation. These symptoms recurred lour rimes for eight months. There were no past personal and family history of mood disorders. Laboratory examinations including electroencephalogram ana endocrinological study did not show any abnormal findings. The rapid cycling secondary manic was relieved by lithium. She was then discharged after 5 months. Mood change was not significant during follow-up while hypomania emerged by dose reduction. The secondary mania seemed to be caused or triggered by the right temporal lobe damage induced by gamma-knife radiosurgery.

Keywords