생물정신의학 (Korean Journal of Biological Psychiatry)

  • 제3권2호
  • /
  • Pages.162-169
  • /
  • 1996
  • /
  • 1225-8709(pISSN)
  • /
  • 2005-7571(eISSN)
대한생물정신의학회 (The Korean Society of Biological Psychiatry)
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한국인 정신분열증 환자와 6번 염색체 D6S274(6p23) 다형성의 연합

An Association Study of a D6S274(6p23) Polymorphism on Chromosome 6 with Korean Schizophrenic Patients

  • 김길숙 (국립서울정신병원) ;
  • 이영호 (인제대학교 의과대학 신경정신과학교실) ;
  • 양병환 (한양대학교 의과대학 신경정신과학교실) ;
  • 한진희 (가톨릭대학교 의과대학 신경정신과학교실) ;
  • 김인 (고려대학교 의과대학 정신과학교실) ;
  • 오동열 (국립서울정신병원) ;
  • 곽상곤 (한양대학교 의과대학 신경정신과학교실) ;
  • 최재영 (노체리안드리 자애병원) ;
  • 엄상화 (인제대학교 의과대학 예방의학교실)
  • Kim, Gil-Sook (Seoul National Mental Hospital) ;
  • Lee, Young-Ho (Department of Neuropsychiatry, Seoul Paik Hospital, Inje University College of Medicine) ;
  • Yang, Byung-Hwan (Department of Neuropsychiatry, Hanyang University) ;
  • Han, Jin-Hee (Department of Neuropsychiatry, St. Vincent Hospital, Catholic University Medical College) ;
  • Kim, Leen (Department of Psychiatry, Korea University College of Medicine) ;
  • Oh, Dong-Yul (Seoul National Mental Hospital) ;
  • Kwak, Sang-Kon (Department of Neuropsychiatry, Hanyang University) ;
  • Choi, Jae-Young (Le Andri Hospital) ;
  • Yrm, Sang-Hwa (Department of Preventive Medicine, Inje University College of Medicine)
  • 발행 : 1996.12.25
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초록

An association study with korean schizophrenic patients(N=75) and normal controls(N=87) was performed to find the relationship between D6S274 polymorphism and schizophrenia using polymerase chain reaction. Nine different alleles of a dinucleotide polymorphism on D6S273 locus were observed in both group. When we compared the frequencies of alleles between schizophrenics and normal controls, there was no significant difference between two groups. To increase homogeneity of schizophrenic group, we divided schizophrenic group by clinical phenotypes such as DSM-IV diagnostic subtype, family history, negative and positive symptoms(PANSS), soft neurologic signs(NES-K). Then we compared the frequencies of alleles among subgroups of clinical phenotypes. there was only significant difference between two subgroups on soft neurologic signs(p<0.05). Although our findings fail to provide on evidence of association between schizophrenia and D6S274 locus, follow-up investigation of this locus may be needed in homogeneous subtypes of schizophrenia and schizophrenic pedigrees.

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