Korean Journal of Biological Psychiatry (생물정신의학)

The Korean Society of Biological Psychiatry (대한생물정신의학회)
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c-fos Expression of Rat Brain by Antipsychotics : Contrasting Effects of Haloperidol and Clozapine

항정신병 약물에 의한 백서 뇌에서의 c-fos 발현 : 할로페리돌과 클로자핀의 효과 비교

  • Lee, Min Soo (Department of Neuropsychiatry, Korea University College of Medicine) ;
  • Han, Chang Su (Department of Neuropsychiatry, Korea University College of Medicine) ;
  • Kim, Jeung Hyun (Department of Neuropsychiatry, Korea University College of Medicine) ;
  • Kim, Young Tae (Department of Obstetrics and Gynecology, Korea University College of Medicine) ;
  • Kwak, Dong Il (Department of Neuropsychiatry, Korea University College of Medicine)
  • 이민수 (고려대학교 의과대학 신경정신과학 교실) ;
  • 한창수 (고려대학교 의과대학 신경정신과학 교실) ;
  • 김정현 (고려대학교 의과대학 신경정신과학 교실) ;
  • 김영태 (고려대학교 의과대학 산부인과학 교실) ;
  • 곽동일 (고려대학교 의과대학 신경정신과학 교실)
  • Published : 1996.06.30
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Abstract

To investigate characteristic drug effects on the genetic basis, the authors administered haloperidol- the $D_2$ antagonist- and clozapine -the atypical antipsychotics with few extra- pyramidal side effects- to the rats. Then, we edobtain brain specimen from the striatum, prefrontal cortex, and cortical region and compared the degree of c-fos expression. The results are 1) haloperidol was found to produce a rapid and transient induction of dos mRNA expression in striatum as compared with cortex and prefrontal area. 2) clozapine was found to produce rapid induction of c-fos mRNA in striatum and prefrontal area. From these data, we can concluded that the mechanism of action of haloperidol is different from the mechanism of clozapine in gene expression.

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Acknowledgement

Supported by : 고려대학교 생명과학연구소