Tuberculosis and Respiratory Diseases
- Volume 43 Issue 3
- /
- Pages.440-448
- /
- 1996
- /
- 1738-3536(pISSN)
- /
- 2005-6184(eISSN)
A Case of atypical bronchial carcinoid with multiple distant metastasis
다발성 원격전이를 보인 비정형 기관지 유암종 1예
- Lee, Tae-Hun (Department of Internal Medicine, Presbyterian Medical Center) ;
- Yang, Sung-Uk (Department of Internal Medicine, Presbyterian Medical Center) ;
- Lee, Tae-Kwan (Department of Internal Medicine, Presbyterian Medical Center) ;
- Kim, Byung-Koo (Department of Internal Medicine, Presbyterian Medical Center) ;
- Kim, Ji-Young (Department of Internal Medicine, Presbyterian Medical Center) ;
- Kim, Kwi-Wan (Department of Internal Medicine, Presbyterian Medical Center) ;
- Lee, Kwang-Min (Department of Anatomical Pathology, Presbyterian Medical Center)
- 이태헌 (전주 예수 병원 내과) ;
- 양성욱 (전주 예수 병원 내과) ;
- 이태관 (전주 예수 병원 내과) ;
- 김병구 (전주 예수 병원 내과) ;
- 김지영 (전주 예수 병원 내과) ;
- 김귀완 (전주 예수 병원 내과) ;
- 이광민 (전주 예수 병원 해부 병리과)
- Published : 1996.06.30
Abstract
Bronchial carcinoid tumors are uncommon, constituting approximately 3-5% of all primary lung cancers. Classification of these tumors has evolved substantially as our understanding of the cellular, biologic, and clinical aspects of these neoplasms has improved. Initially, bronchial carcinoids were thought to be benign and therefore were classified as bronchial adenomas. Currently, however, they are well recognized as having the potential for both local invasion and distant metastatic involvement. Consequently, carcinoid tumors are frankly malignant. Thus bronchial adenoma is a misnomer that should no longer be used for bronchial carcinoids. Most investigators currently favor classifying carcinoid tumors as a type of neuroendocrine neoplasm because of their potential to secrete a variety of chemical substances found in both the central nervous system and the epithelial cells of numerous organs. Bronchial carcinoids are usually characterized by a slow growth pattern and a low incidence of metastasis, and histologically conformed by the azurophil staining and the presence of the characteristic neurosecretary granule on electron microscopy. Atypical carcinoid tumor was first defined by Arrigoni et al, who proposed the following criteria for separation of atypical carcinoid from typical carcinoid tumor : 1) increased mitotic activity with 1 mitotic figure per 1-2 high power fields(or 5-10 mitoses /10 HPF), 2) nuclear pleomorphism, hyperchromatism, and an abnormal nuclear-cytoplasmic ratio, 3) areas of increased cellularity with disorganization of the architecture, and 4) tumor necrosis. In contrast, typical carcinoid tumor may have focal cytologic pleomorphism, but necrosis is absent and mitotic figures are rare. Recently we experienced a case of atypical bronchial carcinoid with multiple distant metastasis, so we report this case with a review of the literature.