YAKHAK HOEJI (약학회지)
- Volume 40 Issue 2
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- Pages.135-140
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- 1996
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
Determination of Verapamil with ISE based on Ion Exchanger
이온교환체 전극을 이용한 베라파밀 정량
- Lee, Eun-Yup (College of Pharmacy, Kyungsung University) ;
- Kim, Dong-O (College of Pharmacy, Kyungsung University) ;
- Chang, Seung-Hyun (Department of Chemistry, Daegu University) ;
- Hur, Moon-Hye (College of Pharmacy, Kyungsung University) ;
- Ahn, Moon-Kyu (College of Pharmacy, Kyungsung University)
- Published : 1996.04.01
Abstract
Ion-selective poly(vinyl chloride)(PVC) membrane electrodes for the determination of the calcium antagonist verapamil and its pharmaceutical preparations were described. Verapam il-superchrome garnet Y(SGY), lumogallion(LG), acid red 97(AR97), Dragendorff(DD) and Meyer reagent ion pairs were inverstigated as an electroactive compound for membrane electrode. Stable potentiometric response was obtained with azo dye at pH 6.5-4.0 and with DD, and Meyer reagent at pH 6.5-3.0. The best plasticizer was 49w/w% 2-nitrophenyl octyl ether for azo dye, and 65.3w/w% tri(n-butyl) citrate for DD and Meyer reagent. Potentiometric response slopes of optimized membrane electrodes based on SGY, LG, AR97, DD, and Meyer complex for verapamil were 52.49, 54.88, 50.81, 54.13 and 49.31 mV/dec., respectively. Lower limits of linear range were
Keywords
- PVC membrane;
- verapamil;
- lumogallion;
- superchrome garnet Y;
- acid red 97;
- Dragendorff reagent;
- Meyer reagent