Acute Subcutaneous Toxicity Study of Syndella Gel, Topical Drug Containing Deproteinised Dialysate of Calf′s Blood and Micronomicin Sulfate in Rats

랫트에 있어서 신델라 겔 (송아지의 제단백혈액추출물: 황산 미크로노마이신=20:1 혼합물)의 피하급성독성시험

Single subcutaneous administration to S.D rats of both sexes was performed to investigate the acute toxicity of Syndella gel, a new topical drug containing deproteinised dialysate of calf's blood and micronomicin sulfate. $LD_{50}$ values for S. D rats were 23,047 mg/kg for male and 23,725 mg/kg for female. The death occurred within 24 hours after administration at doses over 19,200 mg/kg. The main cause of death seemed to be respiratory disturbance by acute shock. Major general symptoms induced by injection subcutaneously with Syndella gel were underactivity, decreased respiratory rate, salivation, tremor and loss of consciousness. No significant body weight changes and gross findings of internal organs in treatment groups in comparison with those of control groups was observed at any dose levels in Syndella gel.