Journal of Nutrition and Health

  • 제29권10호
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  • Pages.1072-1079
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  • 1996
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  • 2288-3886(pISSN)
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  • 2288-3959(eISSN)
한국영양학회 (The Korean Nutrition Society)
권호 표지

식이 단백질 수준이 한쪽 신장을 절제한 흰쥐에서 혈청 지질 및 Eicosanoid 대사에 미치는 영향

Effect of Dietary Protein Level on Renal Function : Lipid and Eicosanoids Metabolism in Uninephrectomized Aging Model in Rats

  • 이현숙 (이화여자대학교 가정과학대학 식품영양학과)
  • 발행 : 1996.12.01
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초록

This study was performed to elucidate the mechanism of dietary protein level on renal function through lipid and eicosanoids metabolism. Male rats of 337.8$\pm$5.7g body weight were undergone unilateral nephrectomy or sham-operation. The rats were divided into high protein(40% casein), normal protein(15% casein) and low protein(8% casein) diet groups and fed experimental diets ad libitum for 24 weeks. The results are summarized as follows. Serum total lipid, cholesterol and HDL-cholesterol of rats in 15% and 40% casein groups were higher than those of 8% casein group. But serum triglyceride was affected neither by uninephrectomy nor by dietary protein level. Serum thromboxane(TX) B2 and 6-keto prostaglandin F1$\alpha$ increased with increasing dietary protein level. Serum prostaglandin(PG) E2 was not affected by uninephrectomy nor by dietary protein level. Urinary PGE2 and TXB2 excretion tended to be lower in uninephrectomized groups. Renal tissue concentration of TXB2 was lower in uninephrectomized groups and in high protein group. These results suggest the possibility that the effects of dietary protein level on renal function could be due to changes in lipid and eicosanoids metabolism.

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참고문헌

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