Journal of Chest Surgery

The Korean Society for Thoracic and Cardiovascular Surgery (대한심장혈관흉부외과학회)
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Pulmonary Autograft with Right Ventricular Outflow Tract Reconstruction in Swine model -1, Feasibility of REV operation-

돼지를 이용한 대동맥 판막에서 자가 폐동맥 판막 이식 및 우심실 유출로 형성술의 신술식 개발 -제1보 REV술식의 적합성 연구-

  • 안재호 (충북대학교 의과대학 흉부외과학교실) ;
  • 노윤우 (충북대학교 의과대학 흉부외과학교실, 충북대학교 의과대학 마취과학교실)
  • Published : 1996.08.01
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Abstract

Ross procedure is an ideal operative modality for diseased aortic valve especially in children, but homogrart for right ventricular outflow tract(RVOT) reconstruction is not easily available in Korea. We tried to perform REV procedure for RVOT reconstruction in 10 young piglets(15.3 $\pm$ 1.3 kg) In an attempt to e clude the use of homograft in Ross operation. 3 of them survived after operation and raised till adult pig(about 70 kg), then examined their pulmonary arteries and hearts. Without any stenotic residues in the great arteries, we only found the deformed monocusp patch with severe calcification, which deprived the adequate valve function, but kept the pig growing normally We are sure that this operative modality (REV + Ross procedure) could be extendedly applied to the diseased human aortic valve, but we need to develope the anti-calcification method for the heterograft patch.

소아에서 대동맥 판막 질환의 경우 합리적인 수술법인 Ross술식을 적용함에 있어,우리 나라의 경우 현실적으로 이용에 어려움이 있는 Ross술식에 필요한 동종이식 판막의 사용을 배제한다는 발상으로 10마리의 15 kg가량의 돼지를 이용 REV술식 등을 시행하고 3마리의 성공 례를 3개월 이상 사육하여 성돈이 된 후 그 판막의 발육 및 기능을 관찰하였다. 대동맥 및 폐동맥 등에 협착의 소견은 없었으며, REV술식으로 사용되었던 monocusp보철편의 변형 및 심한 석회화가 관찰되어 이미 판막으로의 기능 은 상실하였으나 발육에는 큰 지장이 없는 것이 확인되어 REV와 Ross술식의 병행 수술요법이 사람에 서도 적 용될 수 있을 것으로 사료되 며, 계속 석회화 방지에 관한 연구가 진행되면 더욱 좋은 성적을 기대할 수 있겠다.

Keywords

References

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