대한화장품학회지 (Journal of the Society of Cosmetic Scientists of Korea)

  • 제22권1호
  • /
  • Pages.27-39
  • /
  • 1996
  • /
  • 1226-2587(pISSN)
  • /
  • 2288-9507(eISSN)
대한화장품학회 (Society of Cosmetic Scientists of Korea)
권호 표지

노화에 따른 무모 생쥐의 각질층 상태 변화

Alterations of stratum corneum associated with aging in hairkless mouse

  • 박선규 (LG 생활건강 화장품 연구소) ;
  • 김영득 (LG 생활건강 화장품 연구소)
  • 발행 : 1996.03.01
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

최근 in vitro 각질층 모델은 TEWL, 수분보유능 등 피부의 상태변화를 측정하기 위한 유용한 수단으로 이용되고 있다. 본 연구에서는 노화에 따른 각질층의 상태 변화를 조사하기 위하여 in vitro 각질층 모델을 이용한 TEWL 측정, 각질층의 지질분석, 최외각 각질세포의 크기를 측정하였다. 실험 결과, 8주령 무모생쥐의 전체지질은 82 주령 무모생쥐보다 30%가량 많았으나 TEWL은 8주령 무모생쥐가 82주령된 무모생쥐보다 더 높았다. 또한 최외각 각질세포의 크기는 82주령의 무모생쥐가 8주령 보다 더 컸다. 따라서 각질층의 장벽기능은 노화에 따라 오히려 강화되고 있으며 이는 노화에 따른 피부의 활성저하에 대응한 일련의 현상으로 간주된다.

Recently, in vitro stratum curneum model was a useful tool to evaluate the skin condition such as tranespidermal water loss, skin hydration and etc.. In this study to evaluate the alteration of SC with aging in hairless mouse, we measured TEWL using in vitro SC model, SC lipid, and outer corneocytes area. Although the total SC lipid was rich about 30% in 8 week old mouse compared with that of 82 week old mouse, the TEWL values were higher in the former than that of the latter. The outer corneocytes area was 559 $\pm$ 65 $mu extrm{m}$2 in 8 week old mouse and 755 $\pm$ 56 ${\mu}{\textrm}{m}$2 in 82 week old mouse. So the barrier function was reinforced with aging. This result suggested that the reinforced barrier function is one of the defense systems against the outer enviornment and the decreased skin function with aging.

키워드

참고문헌

  1. J. Cell Biol. v.65 the permeability barrier in mammalian epidermis Elias, P.M.;Friend, D.S.
  2. J. Invest Dermatol. v.80 Epidermal lipids, barrier function, and desquamation Elias, P.M.
  3. J. Invest Dermatol. v.104 no.1 Keratinocyte-Keratinocyte Interactions ; Cadherins and Pemphigus Masayuki Amagai;Adhesion Molecules, I.
  4. J. Invest Dermatol. v.104 no.6 Interactions of Keratinocytes with Epidermal Basment Membrane Kim B. Yancey;Adhesion Molecules, II
  5. J. Invest Dermatol. v.103 no.5 Stratum Corneum Moitarization at the Molecular Leve. Rawlings, A.V.;Scitt, I.R.;Harding, C.R.;Bowser, P.A.
  6. J. Invest Dermatol. v.104 no.4 Corneocytes undergo systematic changes in Element Concertrations across the human Inner stratum corneum Warner, R.R.;Bush, R.D.;Ruebusch, N.A.
  7. J. Soc. Cosmet. Chem. v.39 Relationship between skin permeability and coneocyte size according to anatomic sity, ast, and sex in man Rougier, A.;Lotte, C.;Corcuff, P.;Maibach, H.I.
  8. J. Soc. Cosmet. Chem. v.42 Functional changes of the Stratum Corneum associated with aging and photoaging and photoaging Saijo, S.;Hashimoto, K.;Takahashi, M.;Tagami, H.
  9. Measurement of Transepidermal Water Loss(Chap. 7) Cutaneous Investigation in Health and Disease Leveque, J.L.
  10. Advanced in lipid research v.24 The Biochemistry and Fuction of Stratum Corneum Lipids Schurer, N.Y.;Elias, P.M.
  11. Journal of lipid Research v.30 Transepidermal Water loss : the signal for recovery of varrier structure and function Grubauer, G.;Elias, P.M.;Feingold, K.R.
  12. Journal of lipid Research v.28 Relationship of epidermal lipogenesis to cutaneous barrier function Brubauer, G.;Feingald, K.R.;Elias, P.M.